A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia
Peripheral artery disease (PAD) is one of the major vascular complications in individuals suffering from diabetes and in the elderly that can progress to critical limb ischemia (CLI), portending significant burden in terms of patient morbidity and mortality. Over the last two decades, stem cell ther...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3750829 |
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| author | Punam P. Parikh Zhao-Jun Liu Omaida C. Velazquez |
| author_facet | Punam P. Parikh Zhao-Jun Liu Omaida C. Velazquez |
| author_sort | Punam P. Parikh |
| collection | DOAJ |
| description | Peripheral artery disease (PAD) is one of the major vascular complications in individuals suffering from diabetes and in the elderly that can progress to critical limb ischemia (CLI), portending significant burden in terms of patient morbidity and mortality. Over the last two decades, stem cell therapy (SCT) has risen as an attractive alternative to traditional surgical and/or endovascular revascularization to treat this disorder. The primary benefit of SCT is to induce therapeutic neovascularization and promote collateral vessel formation to increase blood flow in the ischemic limb and soft tissue. Existing evidence provides a solid rationale for ongoing in-depth studies aimed at advancing current SCT that may change the way PAD/CLI patients are treated. |
| format | Article |
| id | doaj-art-95cf791986834c17a060b78d17f86e91 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-95cf791986834c17a060b78d17f86e912025-02-03T01:22:08ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/37508293750829A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb IschemiaPunam P. Parikh0Zhao-Jun Liu1Omaida C. Velazquez2DeWitt-Daughtry Family Department of Surgery, Division of Vascular Surgery, University of Miami Miller School of Medicine, Miami, FL, USADeWitt-Daughtry Family Department of Surgery, Division of Vascular Surgery, University of Miami Miller School of Medicine, Miami, FL, USADeWitt-Daughtry Family Department of Surgery, Division of Vascular Surgery, University of Miami Miller School of Medicine, Miami, FL, USAPeripheral artery disease (PAD) is one of the major vascular complications in individuals suffering from diabetes and in the elderly that can progress to critical limb ischemia (CLI), portending significant burden in terms of patient morbidity and mortality. Over the last two decades, stem cell therapy (SCT) has risen as an attractive alternative to traditional surgical and/or endovascular revascularization to treat this disorder. The primary benefit of SCT is to induce therapeutic neovascularization and promote collateral vessel formation to increase blood flow in the ischemic limb and soft tissue. Existing evidence provides a solid rationale for ongoing in-depth studies aimed at advancing current SCT that may change the way PAD/CLI patients are treated.http://dx.doi.org/10.1155/2017/3750829 |
| spellingShingle | Punam P. Parikh Zhao-Jun Liu Omaida C. Velazquez A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia Stem Cells International |
| title | A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia |
| title_full | A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia |
| title_fullStr | A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia |
| title_full_unstemmed | A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia |
| title_short | A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia |
| title_sort | molecular and clinical review of stem cell therapy in critical limb ischemia |
| url | http://dx.doi.org/10.1155/2017/3750829 |
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