Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers
Given the higher mortality rate of ICU patients with sepsis and AKI, we decided to investigate the possible correlation between serum biomarkers of organ damage, and endotoxin activity in ICU septic patients. Ninety-eight consecutive adult patients were enrolled in this study. Patients were divided...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/856401 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563582171086848 |
|---|---|
| author | Paolo Lentini Massimo de Cal Anna Clementi Angela D'Angelo Claudio Ronco |
| author_facet | Paolo Lentini Massimo de Cal Anna Clementi Angela D'Angelo Claudio Ronco |
| author_sort | Paolo Lentini |
| collection | DOAJ |
| description | Given the higher mortality rate of ICU patients with sepsis and AKI, we decided to investigate the possible correlation between serum biomarkers of organ damage, and endotoxin activity in ICU septic patients. Ninety-eight consecutive adult patients were enrolled in this study. Patients were divided in two groups depending on the presence of sepsis. Fifty-six patients had sepsis, while forty-two patients were nonseptic. Among septic patients, twenty-four subjects developed AKI, while thirty-two did not. AKI occurred in fourteen patients without sepsis as well. The levels of NGAL, BNP, and AOPP were significantly higher among septic patients compared with nonseptic subjects (P<0.001). Among septic patients, subjects who developed AKI showed significant higher levels of NGAL and AOPP (P=0.0425) and BNP (P=0.0327). Among patients who developed AKI, a significant difference was found only in terms of AOPP levels between septic and nonseptic patients. The correlation between endotoxin activity and BNP in septic patients and the increase in the levels of NGAL, BNP, and AOPP in case of sepsis and AKI, in particular if they are associated, indicate a multiorgan involvement in these two conditions. |
| format | Article |
| id | doaj-art-95b80a8e269e4785afc19e908f9f6840 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-95b80a8e269e4785afc19e908f9f68402025-02-03T01:13:09ZengWileyCritical Care Research and Practice2090-13052090-13132012-01-01201210.1155/2012/856401856401Sepsis and AKI in ICU Patients: The Role of Plasma BiomarkersPaolo Lentini0Massimo de Cal1Anna Clementi2Angela D'Angelo3Claudio Ronco4Department of Nephrology, San Bassiano Hospital, 36061 Bassano del Grappa, ItalyDivision of Nephrology, University of Padua, 35100 Padua, ItalyDepartment of Nephrology, San Bortolo Hospital, 36100 Vicenza, ItalyDivision of Nephrology, University of Padua, 35100 Padua, ItalyDepartment of Nephrology, San Bortolo Hospital, 36100 Vicenza, ItalyGiven the higher mortality rate of ICU patients with sepsis and AKI, we decided to investigate the possible correlation between serum biomarkers of organ damage, and endotoxin activity in ICU septic patients. Ninety-eight consecutive adult patients were enrolled in this study. Patients were divided in two groups depending on the presence of sepsis. Fifty-six patients had sepsis, while forty-two patients were nonseptic. Among septic patients, twenty-four subjects developed AKI, while thirty-two did not. AKI occurred in fourteen patients without sepsis as well. The levels of NGAL, BNP, and AOPP were significantly higher among septic patients compared with nonseptic subjects (P<0.001). Among septic patients, subjects who developed AKI showed significant higher levels of NGAL and AOPP (P=0.0425) and BNP (P=0.0327). Among patients who developed AKI, a significant difference was found only in terms of AOPP levels between septic and nonseptic patients. The correlation between endotoxin activity and BNP in septic patients and the increase in the levels of NGAL, BNP, and AOPP in case of sepsis and AKI, in particular if they are associated, indicate a multiorgan involvement in these two conditions.http://dx.doi.org/10.1155/2012/856401 |
| spellingShingle | Paolo Lentini Massimo de Cal Anna Clementi Angela D'Angelo Claudio Ronco Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers Critical Care Research and Practice |
| title | Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers |
| title_full | Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers |
| title_fullStr | Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers |
| title_full_unstemmed | Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers |
| title_short | Sepsis and AKI in ICU Patients: The Role of Plasma Biomarkers |
| title_sort | sepsis and aki in icu patients the role of plasma biomarkers |
| url | http://dx.doi.org/10.1155/2012/856401 |
| work_keys_str_mv | AT paololentini sepsisandakiinicupatientstheroleofplasmabiomarkers AT massimodecal sepsisandakiinicupatientstheroleofplasmabiomarkers AT annaclementi sepsisandakiinicupatientstheroleofplasmabiomarkers AT angeladangelo sepsisandakiinicupatientstheroleofplasmabiomarkers AT claudioronco sepsisandakiinicupatientstheroleofplasmabiomarkers |