Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature
Thrombocytopenia as a precipitating factor for pituitary apoplexy (PA) is very rare event. There are only five reported cases of PA secondary to thrombocytopenia caused by underlying haematological malignancy. Herein, we report a case of 60-year-old male presenting with acute-onset headache, bilater...
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/6086756 |
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| author | Rahul Gupta Urmimala Bhattacharjee K. S. Lekshmon Shakun Chaudhary Prashant Sharma Aditya Jandial Pinaki Dutta |
| author_facet | Rahul Gupta Urmimala Bhattacharjee K. S. Lekshmon Shakun Chaudhary Prashant Sharma Aditya Jandial Pinaki Dutta |
| author_sort | Rahul Gupta |
| collection | DOAJ |
| description | Thrombocytopenia as a precipitating factor for pituitary apoplexy (PA) is very rare event. There are only five reported cases of PA secondary to thrombocytopenia caused by underlying haematological malignancy. Herein, we report a case of 60-year-old male presenting with acute-onset headache, bilateral vision loss, and ptosis. Computed tomography and magnetic resonance imaging revealed findings indicative of pituitary adenoma with apoplexy. He was noted to have thrombocytopenia, and bone marrow evaluation revealed precursor B-lineage CALLA-positive acute lymphoblastic leukemia. Accordingly, he was started on dexamethasone and vincristine but succumbed to Acinetobacter baumanii-related hospital-acquired pneumonia two weeks after initiation of chemotherapy. We performed a literature search and found five cases of pituitary apoplexy secondary to haematological malignancy-related thrombocytopenia. The usual age of presentation was in the 6th to 7th decade, and there was slight male preponderance. The underlying pituitary adenoma was either nonfunctioning or a prolactinoma, and in majority, the apoplexy event occurred after the diagnosis of haematological malignancy. The platelet counts at the time of PA were less than 30 × 109/L in all, and the malignancy subtypes were acute or chronic myeloid leukemia and chronic lymphoid leukemia. The current case highlights the importance of careful evaluation for the cause of thrombocytopenia in a case of PA. |
| format | Article |
| id | doaj-art-95a1042d18f8475988a377c9145fea0c |
| institution | Kabale University |
| issn | 2090-651X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-95a1042d18f8475988a377c9145fea0c2025-02-03T05:59:57ZengWileyCase Reports in Endocrinology2090-651X2021-01-01202110.1155/2021/6086756Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the LiteratureRahul Gupta0Urmimala Bhattacharjee1K. S. Lekshmon2Shakun Chaudhary3Prashant Sharma4Aditya Jandial5Pinaki Dutta6Department of EndocrinologyDepartment of Clinical Hematology and Medical OncologyDepartment of Clinical Hematology and Medical OncologyDepartment of EndocrinologyDepartment of Clinical Hematology and Medical OncologyDepartment of Clinical Hematology and Medical OncologyDepartment of EndocrinologyThrombocytopenia as a precipitating factor for pituitary apoplexy (PA) is very rare event. There are only five reported cases of PA secondary to thrombocytopenia caused by underlying haematological malignancy. Herein, we report a case of 60-year-old male presenting with acute-onset headache, bilateral vision loss, and ptosis. Computed tomography and magnetic resonance imaging revealed findings indicative of pituitary adenoma with apoplexy. He was noted to have thrombocytopenia, and bone marrow evaluation revealed precursor B-lineage CALLA-positive acute lymphoblastic leukemia. Accordingly, he was started on dexamethasone and vincristine but succumbed to Acinetobacter baumanii-related hospital-acquired pneumonia two weeks after initiation of chemotherapy. We performed a literature search and found five cases of pituitary apoplexy secondary to haematological malignancy-related thrombocytopenia. The usual age of presentation was in the 6th to 7th decade, and there was slight male preponderance. The underlying pituitary adenoma was either nonfunctioning or a prolactinoma, and in majority, the apoplexy event occurred after the diagnosis of haematological malignancy. The platelet counts at the time of PA were less than 30 × 109/L in all, and the malignancy subtypes were acute or chronic myeloid leukemia and chronic lymphoid leukemia. The current case highlights the importance of careful evaluation for the cause of thrombocytopenia in a case of PA.http://dx.doi.org/10.1155/2021/6086756 |
| spellingShingle | Rahul Gupta Urmimala Bhattacharjee K. S. Lekshmon Shakun Chaudhary Prashant Sharma Aditya Jandial Pinaki Dutta Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature Case Reports in Endocrinology |
| title | Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature |
| title_full | Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature |
| title_fullStr | Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature |
| title_full_unstemmed | Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature |
| title_short | Acute Lymphoblastic Leukemia Presenting as Pituitary Apoplexy: A Case Report and Review of the Literature |
| title_sort | acute lymphoblastic leukemia presenting as pituitary apoplexy a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2021/6086756 |
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