Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of z...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/620581 |
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| author | Marjana Brkic Sriram Balusu Claude Libert Roosmarijn E. Vandenbroucke |
| author_facet | Marjana Brkic Sriram Balusu Claude Libert Roosmarijn E. Vandenbroucke |
| author_sort | Marjana Brkic |
| collection | DOAJ |
| description | Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases. |
| format | Article |
| id | doaj-art-959cfdce80314c99a57bb77fd4cc90cc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-959cfdce80314c99a57bb77fd4cc90cc2025-02-03T05:50:28ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/620581620581Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative DiseasesMarjana Brkic0Sriram Balusu1Claude Libert2Roosmarijn E. Vandenbroucke3Inflammation Research Center, VIB, 9052 Ghent, BelgiumInflammation Research Center, VIB, 9052 Ghent, BelgiumInflammation Research Center, VIB, 9052 Ghent, BelgiumInflammation Research Center, VIB, 9052 Ghent, BelgiumNeurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.http://dx.doi.org/10.1155/2015/620581 |
| spellingShingle | Marjana Brkic Sriram Balusu Claude Libert Roosmarijn E. Vandenbroucke Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases Mediators of Inflammation |
| title | Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases |
| title_full | Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases |
| title_fullStr | Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases |
| title_full_unstemmed | Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases |
| title_short | Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases |
| title_sort | friends or foes matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases |
| url | http://dx.doi.org/10.1155/2015/620581 |
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