Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes
Obesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on adipogenesis and lipolysis. Treatment with CM o...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
|
| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13930 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544072847327232 |
|---|---|
| author | Kazuya Kusama Kodai Oka Yumi Yashiro Kanoko Yoshida Hiroaki Miyaoka Kazuhiro Tamura |
| author_facet | Kazuya Kusama Kodai Oka Yumi Yashiro Kanoko Yoshida Hiroaki Miyaoka Kazuhiro Tamura |
| author_sort | Kazuya Kusama |
| collection | DOAJ |
| description | Obesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on adipogenesis and lipolysis. Treatment with CM or cordycepin reduced lipid droplets and increased hormone‐sensitive lipase activation in 3T3‐L1 cells. In a diabetic obese mouse model, CM and cordycepin lowered serum low‐density lipoprotein/very low‐density lipoprotein levels and reduced oxidative stress and cell senescence markers. Thus, cordycepin inhibits preadipocyte differentiation and promotes lipolysis, which may serve as a novel obesity treatment. Further studies, including clinical trials, are required to validate the clinical potential of cordycepin. |
| format | Article |
| id | doaj-art-95704ee9f46e47d783cd00514b841cf6 |
| institution | Kabale University |
| issn | 2211-5463 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj-art-95704ee9f46e47d783cd00514b841cf62025-02-03T10:59:31ZengWileyFEBS Open Bio2211-54632025-02-0115233534510.1002/2211-5463.13930Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytesKazuya Kusama0Kodai Oka1Yumi Yashiro2Kanoko Yoshida3Hiroaki Miyaoka4Kazuhiro Tamura5Department of Endocrine Pharmacology Tokyo University of Pharmacy and Life Sciences JapanDepartment of Endocrine Pharmacology Tokyo University of Pharmacy and Life Sciences JapanDepartment of Endocrine Pharmacology Tokyo University of Pharmacy and Life Sciences JapanDepartment of Endocrine Pharmacology Tokyo University of Pharmacy and Life Sciences JapanDepartment of Biomolecular Organic Chemistry Tokyo University of Pharmacy and Life Sciences JapanDepartment of Endocrine Pharmacology Tokyo University of Pharmacy and Life Sciences JapanObesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on adipogenesis and lipolysis. Treatment with CM or cordycepin reduced lipid droplets and increased hormone‐sensitive lipase activation in 3T3‐L1 cells. In a diabetic obese mouse model, CM and cordycepin lowered serum low‐density lipoprotein/very low‐density lipoprotein levels and reduced oxidative stress and cell senescence markers. Thus, cordycepin inhibits preadipocyte differentiation and promotes lipolysis, which may serve as a novel obesity treatment. Further studies, including clinical trials, are required to validate the clinical potential of cordycepin.https://doi.org/10.1002/2211-5463.13930adipocytecell senescencecordycepinCordyceps militarisoxidative stress |
| spellingShingle | Kazuya Kusama Kodai Oka Yumi Yashiro Kanoko Yoshida Hiroaki Miyaoka Kazuhiro Tamura Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes FEBS Open Bio adipocyte cell senescence cordycepin Cordyceps militaris oxidative stress |
| title | Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes |
| title_full | Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes |
| title_fullStr | Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes |
| title_full_unstemmed | Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes |
| title_short | Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes |
| title_sort | effect of cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes |
| topic | adipocyte cell senescence cordycepin Cordyceps militaris oxidative stress |
| url | https://doi.org/10.1002/2211-5463.13930 |
| work_keys_str_mv | AT kazuyakusama effectofcordycepsmilitarisextractcontainingcordycepinontheadipogenesisandlipolysisofadipocytes AT kodaioka effectofcordycepsmilitarisextractcontainingcordycepinontheadipogenesisandlipolysisofadipocytes AT yumiyashiro effectofcordycepsmilitarisextractcontainingcordycepinontheadipogenesisandlipolysisofadipocytes AT kanokoyoshida effectofcordycepsmilitarisextractcontainingcordycepinontheadipogenesisandlipolysisofadipocytes AT hiroakimiyaoka effectofcordycepsmilitarisextractcontainingcordycepinontheadipogenesisandlipolysisofadipocytes AT kazuhirotamura effectofcordycepsmilitarisextractcontainingcordycepinontheadipogenesisandlipolysisofadipocytes |