Gene Array Studies in Renal Neoplasia
Renal cell carcinoma (RCC) is comprised of several distinct histologic subtypes many of which have characteristic cytogenetic abnormalities. The molecular pathogenesis of some of these neoplasms is beginning to be elucidated. Yet renal cell carcinoma is often discovered at an advanced clinical stage...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.109 |
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| author | John P.T. Higgins |
| author_facet | John P.T. Higgins |
| author_sort | John P.T. Higgins |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is comprised of several distinct histologic subtypes many of which have characteristic cytogenetic abnormalities. The molecular pathogenesis of some of these neoplasms is beginning to be elucidated. Yet renal cell carcinoma is often discovered at an advanced clinical stage and effective pharmacologic therapies for this disease remain to be discovered. For these reasons, renal cell carcinoma is ideally suited to the genome scale investigation made possible by DNA microarrays. A number of DNA array studies of renal cell carcinoma have been published. Renal cell carcinomas have also been studied by array based comparative genomic hybridization. The purpose of this review will be to summarize these studies, to compare the results of the different studies, and to suggest future areas of investigation with a particular emphasis on clinically relevant advances. |
| format | Article |
| id | doaj-art-956f52cc787e466e92c243852dfbbd82 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-956f52cc787e466e92c243852dfbbd822025-02-03T06:08:31ZengWileyThe Scientific World Journal1537-744X2006-01-01650251110.1100/tsw.2006.109Gene Array Studies in Renal NeoplasiaJohn P.T. Higgins0Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USARenal cell carcinoma (RCC) is comprised of several distinct histologic subtypes many of which have characteristic cytogenetic abnormalities. The molecular pathogenesis of some of these neoplasms is beginning to be elucidated. Yet renal cell carcinoma is often discovered at an advanced clinical stage and effective pharmacologic therapies for this disease remain to be discovered. For these reasons, renal cell carcinoma is ideally suited to the genome scale investigation made possible by DNA microarrays. A number of DNA array studies of renal cell carcinoma have been published. Renal cell carcinomas have also been studied by array based comparative genomic hybridization. The purpose of this review will be to summarize these studies, to compare the results of the different studies, and to suggest future areas of investigation with a particular emphasis on clinically relevant advances.http://dx.doi.org/10.1100/tsw.2006.109 |
| spellingShingle | John P.T. Higgins Gene Array Studies in Renal Neoplasia The Scientific World Journal |
| title | Gene Array Studies in Renal Neoplasia |
| title_full | Gene Array Studies in Renal Neoplasia |
| title_fullStr | Gene Array Studies in Renal Neoplasia |
| title_full_unstemmed | Gene Array Studies in Renal Neoplasia |
| title_short | Gene Array Studies in Renal Neoplasia |
| title_sort | gene array studies in renal neoplasia |
| url | http://dx.doi.org/10.1100/tsw.2006.109 |
| work_keys_str_mv | AT johnpthiggins genearraystudiesinrenalneoplasia |