Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling
Abstract In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for the first time at different temperatures and pressure values ranging from 308 to 338 K and 12 to 30 MPa, respectively. The determined experimental molar solubilities of...
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2025-01-01
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| author | Seyed Ali Sajadian Nadia Esfandiari Adrián Rojas Salar Hemmati Abolghasem Jouyban Gonzalo Aguila Chandrasekhar Garlapati |
| author_facet | Seyed Ali Sajadian Nadia Esfandiari Adrián Rojas Salar Hemmati Abolghasem Jouyban Gonzalo Aguila Chandrasekhar Garlapati |
| author_sort | Seyed Ali Sajadian |
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| description | Abstract In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for the first time at different temperatures and pressure values ranging from 308 to 338 K and 12 to 30 MPa, respectively. The determined experimental molar solubilities of mesalazine in supercritical carbon dioxide were in the range of 4.41 × 10–5 to 9.97 × 10–5 (308 K), 3.9 × 10–5 to 13.1 × 10–5 (318 K), 3.4 × 10–5 to 16 × 10–5 (328 K) and 3.3 × 10–5 to 18.4 × 10–5 (338 K). Meanwhile, the determined experimental molar solubilities in supercritical carbon dioxide using 2% dimethyl sulfoxide as cosolvent were in the range of 28.22 × 10–5 to 36.2 × 10–5 (308 K), 26.07 × 10–5 to 51.41 × 10–5 (318 K), 25.02 × 10–5 to 69.07 × 10–5 (328 K) and 25.86 × 10–5 to 82.6 × 10–5 (338 K). A novel association model was employed to simulate the solubility data of the binary and ternary systems. Various semiempirical correlations were utilized to calculate the solubility of mesalazine in supercritical carbon dioxide. The new association model was deemed the most superior model, achieving an average absolute relative deviation value of 4.13% without a cosolvent, and 3.36% when a cosolvent was included. |
| format | Article |
| id | doaj-art-956c8129f07a458394d15244d1787e27 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-956c8129f07a458394d15244d1787e272025-02-02T12:23:02ZengNature PortfolioScientific Reports2045-23222025-01-0115112110.1038/s41598-025-86004-zMesalazine solubility in supercritical carbon dioxide with and without cosolvent and modelingSeyed Ali Sajadian0Nadia Esfandiari1Adrián Rojas2Salar Hemmati3Abolghasem Jouyban4Gonzalo Aguila5Chandrasekhar Garlapati6Department of Chemical Engineering, Faculty of Engineering, University of KashanDepartment of Chemical Engineering, Marvdasht Branch, Islamic Azad UniversityPackaging Innovation Center (LABEN), Department of Science and Food Technology, Faculty of Technology, University of Santiago of Chile (USACH)Drug Applied Research Center, Tabriz University of Medical SciencesPharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical SciencesDepartamento de Ciencias de La Ingeniería, Facultad de Ingeniería, Universidad Andres BelloDepartment of Chemical Engineering, Puducherry Technological UniversityAbstract In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for the first time at different temperatures and pressure values ranging from 308 to 338 K and 12 to 30 MPa, respectively. The determined experimental molar solubilities of mesalazine in supercritical carbon dioxide were in the range of 4.41 × 10–5 to 9.97 × 10–5 (308 K), 3.9 × 10–5 to 13.1 × 10–5 (318 K), 3.4 × 10–5 to 16 × 10–5 (328 K) and 3.3 × 10–5 to 18.4 × 10–5 (338 K). Meanwhile, the determined experimental molar solubilities in supercritical carbon dioxide using 2% dimethyl sulfoxide as cosolvent were in the range of 28.22 × 10–5 to 36.2 × 10–5 (308 K), 26.07 × 10–5 to 51.41 × 10–5 (318 K), 25.02 × 10–5 to 69.07 × 10–5 (328 K) and 25.86 × 10–5 to 82.6 × 10–5 (338 K). A novel association model was employed to simulate the solubility data of the binary and ternary systems. Various semiempirical correlations were utilized to calculate the solubility of mesalazine in supercritical carbon dioxide. The new association model was deemed the most superior model, achieving an average absolute relative deviation value of 4.13% without a cosolvent, and 3.36% when a cosolvent was included.https://doi.org/10.1038/s41598-025-86004-zCosolventDensity modelsNew association modelSupercritical carbon dioxideMesalazineSolubility |
| spellingShingle | Seyed Ali Sajadian Nadia Esfandiari Adrián Rojas Salar Hemmati Abolghasem Jouyban Gonzalo Aguila Chandrasekhar Garlapati Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling Scientific Reports Cosolvent Density models New association model Supercritical carbon dioxide Mesalazine Solubility |
| title | Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling |
| title_full | Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling |
| title_fullStr | Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling |
| title_full_unstemmed | Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling |
| title_short | Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling |
| title_sort | mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling |
| topic | Cosolvent Density models New association model Supercritical carbon dioxide Mesalazine Solubility |
| url | https://doi.org/10.1038/s41598-025-86004-z |
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