A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm

A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm

The chlorinated paraffin (CP) monomer 1,2,5,6,9,10-Hexachlorodecane (CP-4) was subjected to in vitro biotransformation using human and carp liver microsomes. Five types of CP-4 metabolites (OH–, keto-, enol-, aldehyde- and carboxy-CP-4) were identified in human liver microsomer while only mono-OH-CP...

Full description

Saved in:
Bibliographic Details
Main Authors: Liujun Chen, Caiming Tang, Zhiqiang Yu, Yanhong Zeng, Bixian Mai, Xiaojun Luo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Environment International
Subjects:
Chlorinated Paraffins
Biotransformation
Liver microsomes
Metabolites
Toxicity assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412024008225
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items