Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study
The limitations of pharmacological treatments for chronic pain have become increasingly evident: dependency, side effects, resistance, and diminishing efficacy. The urgent need for innovative solutions has become a compelling focus for improving patient outcomes. Innovative non-pharmacological appro...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2076-328X/15/1/40 |
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| author | Sonia López-Monzoni Gloria Hernando Benito Sofía Romero-Peralta Laura Silgado-Martínez Maria Esther Viejo-Ayuso Leticia Álvarez-Balado Enrique Rodríguez Matarranz Carles Forné Izquierdo Manuel Sánchez-de-la-Torre Juan Fernando Masa Ferrán Barbé Francisco García-Río Antonio Martínez-Nicolás Belén García-Mediano Esther Solano-Pérez Olga Mediano |
| author_facet | Sonia López-Monzoni Gloria Hernando Benito Sofía Romero-Peralta Laura Silgado-Martínez Maria Esther Viejo-Ayuso Leticia Álvarez-Balado Enrique Rodríguez Matarranz Carles Forné Izquierdo Manuel Sánchez-de-la-Torre Juan Fernando Masa Ferrán Barbé Francisco García-Río Antonio Martínez-Nicolás Belén García-Mediano Esther Solano-Pérez Olga Mediano |
| author_sort | Sonia López-Monzoni |
| collection | DOAJ |
| description | The limitations of pharmacological treatments for chronic pain have become increasingly evident: dependency, side effects, resistance, and diminishing efficacy. The urgent need for innovative solutions has become a compelling focus for improving patient outcomes. Innovative non-pharmacological approaches, such as sleep management, as a strategy to reduce opioid consumption and pain control are needed. The aim was to evaluate the impact of a Sleep and Circadian Intervention Program (SCIP) in the control of chronic musculoskeletal pain (CMP). This was a randomized clinical trial (NCT03646084), in which 49 CMP patients were assigned to SCIP (<i>n</i> = 15, mean age 51 years and 40% women) or non-SCIP groups (<i>n</i> = 26, 53 years and 61.5% women). Outcomes were evaluated after 6 months through self-reported questionnaires (pain intensity, physical function, depression/anxiety, and quality of life (QoL)). The SCIP group was assessed by polysomnography and specific questionnaires and was treated for diagnosed sleep disorders according to clinical guidelines. This population showed a moderate pain intensity at baseline, important deterioration of QoL and pathological anxiety/fear related to pain. Fifty percent of them presented restless leg syndrome, 60% moderate/severe insomnia, and 62.5% sleep apnea. During the follow-up, the SCIP group presented a greater reduction in the abnormal risk group for anxiety (from 73.3% to 46.7%) and depression (from 53.3% to 33.3%) on the Hospital Anxiety and Depression Scale compared to the non-SCIP group (from 40% to 29.2% and 33.3% to 29.2%, respectively). Also, a positive significant effect on anxiety/fear related to pain was found in the Pain Anxiety Symptoms Scale multivariable model, with an important improvement in symptoms. The application of SCIP in CMP patients improved anxiety and controlled associated sleep disorders, highlighting the impact on insomnia. Larger studies are needed for better understanding of the sleep intervention in CMP control. |
| format | Article |
| id | doaj-art-95574ae6ac8f43f69ed96dba6e834ceb |
| institution | Kabale University |
| issn | 2076-328X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Behavioral Sciences |
| spelling | doaj-art-95574ae6ac8f43f69ed96dba6e834ceb2025-01-24T13:22:42ZengMDPI AGBehavioral Sciences2076-328X2025-01-011514010.3390/bs15010040Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot StudySonia López-Monzoni0Gloria Hernando Benito1Sofía Romero-Peralta2Laura Silgado-Martínez3Maria Esther Viejo-Ayuso4Leticia Álvarez-Balado5Enrique Rodríguez Matarranz6Carles Forné Izquierdo7Manuel Sánchez-de-la-Torre8Juan Fernando Masa9Ferrán Barbé10Francisco García-Río11Antonio Martínez-Nicolás12Belén García-Mediano13Esther Solano-Pérez14Olga Mediano15Sleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainMedicine Department, Universidad de Alcalá, 28805 Madrid, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainAnesthesiology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainHeorfy Consulting, 25007 Lleida, SpainGroup of Precision Medicine in Chronic Diseases, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla La Mancha (IDISCAM), 45071 Toledo, SpainCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, SpainChronobiology Lab, Department of Physiology, College of Biology, Universidad de Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, 30100 Murcia, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainSleep Unit, Pneumology Department, Hospital Universitario de Guadalajara, 19002 Guadalajara, SpainThe limitations of pharmacological treatments for chronic pain have become increasingly evident: dependency, side effects, resistance, and diminishing efficacy. The urgent need for innovative solutions has become a compelling focus for improving patient outcomes. Innovative non-pharmacological approaches, such as sleep management, as a strategy to reduce opioid consumption and pain control are needed. The aim was to evaluate the impact of a Sleep and Circadian Intervention Program (SCIP) in the control of chronic musculoskeletal pain (CMP). This was a randomized clinical trial (NCT03646084), in which 49 CMP patients were assigned to SCIP (<i>n</i> = 15, mean age 51 years and 40% women) or non-SCIP groups (<i>n</i> = 26, 53 years and 61.5% women). Outcomes were evaluated after 6 months through self-reported questionnaires (pain intensity, physical function, depression/anxiety, and quality of life (QoL)). The SCIP group was assessed by polysomnography and specific questionnaires and was treated for diagnosed sleep disorders according to clinical guidelines. This population showed a moderate pain intensity at baseline, important deterioration of QoL and pathological anxiety/fear related to pain. Fifty percent of them presented restless leg syndrome, 60% moderate/severe insomnia, and 62.5% sleep apnea. During the follow-up, the SCIP group presented a greater reduction in the abnormal risk group for anxiety (from 73.3% to 46.7%) and depression (from 53.3% to 33.3%) on the Hospital Anxiety and Depression Scale compared to the non-SCIP group (from 40% to 29.2% and 33.3% to 29.2%, respectively). Also, a positive significant effect on anxiety/fear related to pain was found in the Pain Anxiety Symptoms Scale multivariable model, with an important improvement in symptoms. The application of SCIP in CMP patients improved anxiety and controlled associated sleep disorders, highlighting the impact on insomnia. Larger studies are needed for better understanding of the sleep intervention in CMP control.https://www.mdpi.com/2076-328X/15/1/40chronic painsleepsleep disorderscircadian rhythmanxietydepression |
| spellingShingle | Sonia López-Monzoni Gloria Hernando Benito Sofía Romero-Peralta Laura Silgado-Martínez Maria Esther Viejo-Ayuso Leticia Álvarez-Balado Enrique Rodríguez Matarranz Carles Forné Izquierdo Manuel Sánchez-de-la-Torre Juan Fernando Masa Ferrán Barbé Francisco García-Río Antonio Martínez-Nicolás Belén García-Mediano Esther Solano-Pérez Olga Mediano Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study Behavioral Sciences chronic pain sleep sleep disorders circadian rhythm anxiety depression |
| title | Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study |
| title_full | Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study |
| title_fullStr | Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study |
| title_full_unstemmed | Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study |
| title_short | Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study |
| title_sort | improving anxiety related to chronic pain through a sleep circadian intervention program a pilot study |
| topic | chronic pain sleep sleep disorders circadian rhythm anxiety depression |
| url | https://www.mdpi.com/2076-328X/15/1/40 |
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