Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog
A 3-year-old female spayed rat terrier presented for hyperactivity and repetitive circling to the right of less than one-hour duration. On examination, the patient was dehydrated, hyperactive, and dysphoric. Laboratory tests initially revealed elevations in creatine kinase (CK) and aspartate aminotr...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Veterinary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/2816373 |
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| author | M. Ryan Smith Virginie A. Wurlod |
| author_facet | M. Ryan Smith Virginie A. Wurlod |
| author_sort | M. Ryan Smith |
| collection | DOAJ |
| description | A 3-year-old female spayed rat terrier presented for hyperactivity and repetitive circling to the right of less than one-hour duration. On examination, the patient was dehydrated, hyperactive, and dysphoric. Laboratory tests initially revealed elevations in creatine kinase (CK) and aspartate aminotransferase (AST). Serial chemistries indicated significant progression of CK elevation to a maximum of 181,900 U/L on day 3 along with the development of profuse myoglobinuria. A urine drug screening test was positive for amphetamine metabolites. This patient was treated with sedatives, aggressive fluid diuresis, and antioxidants. The dog recovered uneventfully with no indicators of renal dysfunction based on serial blood chemistries and was discharged five days after presentation. Follow-up blood chemistries taken four days after discharge revealed near normalization of CK and resolution of myoglobinuria. This case report describes a particularly severe case of rhabdomyolysis associated with amphetamine toxicity and its successful treatment. |
| format | Article |
| id | doaj-art-954a482fb46f47ef86ae6dd891e45a28 |
| institution | Kabale University |
| issn | 2090-7001 2090-701X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Veterinary Medicine |
| spelling | doaj-art-954a482fb46f47ef86ae6dd891e45a282025-02-03T06:43:40ZengWileyCase Reports in Veterinary Medicine2090-70012090-701X2020-01-01202010.1155/2020/28163732816373Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a DogM. Ryan Smith0Virginie A. Wurlod1Department of Veterinary Clinical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USADepartment of Veterinary Clinical Sciences, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USAA 3-year-old female spayed rat terrier presented for hyperactivity and repetitive circling to the right of less than one-hour duration. On examination, the patient was dehydrated, hyperactive, and dysphoric. Laboratory tests initially revealed elevations in creatine kinase (CK) and aspartate aminotransferase (AST). Serial chemistries indicated significant progression of CK elevation to a maximum of 181,900 U/L on day 3 along with the development of profuse myoglobinuria. A urine drug screening test was positive for amphetamine metabolites. This patient was treated with sedatives, aggressive fluid diuresis, and antioxidants. The dog recovered uneventfully with no indicators of renal dysfunction based on serial blood chemistries and was discharged five days after presentation. Follow-up blood chemistries taken four days after discharge revealed near normalization of CK and resolution of myoglobinuria. This case report describes a particularly severe case of rhabdomyolysis associated with amphetamine toxicity and its successful treatment.http://dx.doi.org/10.1155/2020/2816373 |
| spellingShingle | M. Ryan Smith Virginie A. Wurlod Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog Case Reports in Veterinary Medicine |
| title | Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog |
| title_full | Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog |
| title_fullStr | Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog |
| title_full_unstemmed | Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog |
| title_short | Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog |
| title_sort | severe rhabdomyolysis associated with acute amphetamine toxicosis in a dog |
| url | http://dx.doi.org/10.1155/2020/2816373 |
| work_keys_str_mv | AT mryansmith severerhabdomyolysisassociatedwithacuteamphetaminetoxicosisinadog AT virginieawurlod severerhabdomyolysisassociatedwithacuteamphetaminetoxicosisinadog |