<i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation
<i>Phyllanthus emblica</i> is widely used in Ayurvedic preparations against multiple disorders and contains various bioactive components. This study aimed to determine the preventive effect of <i>P. emblica</i> on obesity by evaluating the inhibition of adipogenesis and the r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/14/2/160 |
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| author | Seon Kyeong Park Yu Geon Lee Jae-In Lee Min-Sun Kim Jae-Ho Park Jin-Taek Hwang Min-Yu Chung |
| author_facet | Seon Kyeong Park Yu Geon Lee Jae-In Lee Min-Sun Kim Jae-Ho Park Jin-Taek Hwang Min-Yu Chung |
| author_sort | Seon Kyeong Park |
| collection | DOAJ |
| description | <i>Phyllanthus emblica</i> is widely used in Ayurvedic preparations against multiple disorders and contains various bioactive components. This study aimed to determine the preventive effect of <i>P. emblica</i> on obesity by evaluating the inhibition of adipogenesis and the related regulatory epigenetic mechanisms during 3T3-L1 differentiation. The ethyl acetate fraction of <i>P. emblica</i> (EFPE) effectively inhibited lipid accumulation and triglyceride (TG) production in 3T3-L1 adipocytes. It also inhibited histone acetyltransferase (HAT) activity and regulated Pcaf-specific H3K9 acetylation and the expression of adipogenesis-related genes during adipocyte differentiation. Phenolic compounds were the main components of EFPE, of which gallic acid (GA) exhibited the strongest inhibitory effect on lipid accumulation and TG production. Notably, GA effectively regulated adipogenesis-mediated gene expression through H3K9 acetylation. These findings, along with the experiment results, suggest that EFPE containing GA is a potent agent for preventing obesity by regulating H3K9 acetylation. |
| format | Article |
| id | doaj-art-95229a3768bc4f84bde697153faa6c0d |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-95229a3768bc4f84bde697153faa6c0d2025-01-24T13:32:41ZengMDPI AGFoods2304-81582025-01-0114216010.3390/foods14020160<i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone AcetylationSeon Kyeong Park0Yu Geon Lee1Jae-In Lee2Min-Sun Kim3Jae-Ho Park4Jin-Taek Hwang5Min-Yu Chung6Food Functionality Research Division, Korea Food Research Institute (KFRI), Wanju-gun 55365, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute (KFRI), Wanju-gun 55365, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute (KFRI), Wanju-gun 55365, Republic of KoreaFood Industry Research Division, Korea Food Research Institute (KFRI), Wanju-gun 55365, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute (KFRI), Wanju-gun 55365, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute (KFRI), Wanju-gun 55365, Republic of KoreaDepartment of Food and Nutrition, Gangseo University, Seoul 07661, Republic of Korea<i>Phyllanthus emblica</i> is widely used in Ayurvedic preparations against multiple disorders and contains various bioactive components. This study aimed to determine the preventive effect of <i>P. emblica</i> on obesity by evaluating the inhibition of adipogenesis and the related regulatory epigenetic mechanisms during 3T3-L1 differentiation. The ethyl acetate fraction of <i>P. emblica</i> (EFPE) effectively inhibited lipid accumulation and triglyceride (TG) production in 3T3-L1 adipocytes. It also inhibited histone acetyltransferase (HAT) activity and regulated Pcaf-specific H3K9 acetylation and the expression of adipogenesis-related genes during adipocyte differentiation. Phenolic compounds were the main components of EFPE, of which gallic acid (GA) exhibited the strongest inhibitory effect on lipid accumulation and TG production. Notably, GA effectively regulated adipogenesis-mediated gene expression through H3K9 acetylation. These findings, along with the experiment results, suggest that EFPE containing GA is a potent agent for preventing obesity by regulating H3K9 acetylation.https://www.mdpi.com/2304-8158/14/2/160<i>Phyllanthus emblica</i>adipogenesisgallic acidhistone acetylationH3K9ac |
| spellingShingle | Seon Kyeong Park Yu Geon Lee Jae-In Lee Min-Sun Kim Jae-Ho Park Jin-Taek Hwang Min-Yu Chung <i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation Foods <i>Phyllanthus emblica</i> adipogenesis gallic acid histone acetylation H3K9ac |
| title | <i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation |
| title_full | <i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation |
| title_fullStr | <i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation |
| title_full_unstemmed | <i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation |
| title_short | <i>Phyllanthus emblica</i> Prevents Adipogenesis by Regulating Histone Acetylation |
| title_sort | i phyllanthus emblica i prevents adipogenesis by regulating histone acetylation |
| topic | <i>Phyllanthus emblica</i> adipogenesis gallic acid histone acetylation H3K9ac |
| url | https://www.mdpi.com/2304-8158/14/2/160 |
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