Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents
Objective: This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults. Methods: The study involved 11 older adul...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524003085 |
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| author | Erivaldo Machado Araújo Hélio José Coelho-Júnior Caio Victor Sousa Thiago dos Santos Rosa Ivo Vieira Sousa Neto Emanuele Marzetti Octávio Luiz Franco Samuel da Silva Aguiar |
| author_facet | Erivaldo Machado Araújo Hélio José Coelho-Júnior Caio Victor Sousa Thiago dos Santos Rosa Ivo Vieira Sousa Neto Emanuele Marzetti Octávio Luiz Franco Samuel da Silva Aguiar |
| author_sort | Erivaldo Machado Araújo |
| collection | DOAJ |
| description | Objective: This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults. Methods: The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14–15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2–13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation. Results: Dual-task RT significantly enhanced balance (p = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (p = 0.008) and post-detraining (p = 0.015) relative to baseline. Cognitive ability showed significant improvements (p < 0.05). The CAT/TBARS ratio increased significantly post-training (p < 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (p < 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p < 0.05). Conclusion: Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining. |
| format | Article |
| id | doaj-art-950d5d1fbbe74212a4c80e61e4d314d6 |
| institution | Kabale University |
| issn | 1873-6815 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj-art-950d5d1fbbe74212a4c80e61e4d314d62025-01-31T05:10:05ZengElsevierExperimental Gerontology1873-68152025-02-01200112662Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residentsErivaldo Machado Araújo0Hélio José Coelho-Júnior1Caio Victor Sousa2Thiago dos Santos Rosa3Ivo Vieira Sousa Neto4Emanuele Marzetti5Octávio Luiz Franco6Samuel da Silva Aguiar7Postgraduate Program in Physical Education, Federal University of Mato Grosso, Cuiabá, MT, BrazilFondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of Health and Human Sciences, Loyola Marymount University, Los Angeles, United States of AmericaGraduate Program in Physical Education and Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Taguatinga, BrazilSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, BrazilFondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy; Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Correspondence to: E. Marzetti, Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy; Correspondence to: E. Marzetti, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy.Center for Proteomic and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil; S-Inova Biotech, Postgraduate Program in Biotechnology, Catholic University Dom Bosco (UCDB), Campo Grande, BrazilPostgraduate Program in Physical Education, Federal University of Mato Grosso, Cuiabá, MT, Brazil; Center for Proteomic and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, Brazil; Correspondence to: S.d.S. Aguiar, Sede SEP/SUL EQ704/904 Conj. A Brasília – DF, 70.390-045, Brazil.Objective: This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults. Methods: The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14–15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2–13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation. Results: Dual-task RT significantly enhanced balance (p = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (p = 0.008) and post-detraining (p = 0.015) relative to baseline. Cognitive ability showed significant improvements (p < 0.05). The CAT/TBARS ratio increased significantly post-training (p < 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (p < 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p < 0.05). Conclusion: Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining.http://www.sciencedirect.com/science/article/pii/S0531556524003085Physical exerciseDual taskingRedox balanceInflammatory profileolder adults |
| spellingShingle | Erivaldo Machado Araújo Hélio José Coelho-Júnior Caio Victor Sousa Thiago dos Santos Rosa Ivo Vieira Sousa Neto Emanuele Marzetti Octávio Luiz Franco Samuel da Silva Aguiar Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents Experimental Gerontology Physical exercise Dual tasking Redox balance Inflammatory profile older adults |
| title | Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents |
| title_full | Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents |
| title_fullStr | Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents |
| title_full_unstemmed | Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents |
| title_short | Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents |
| title_sort | improving serum redox balance inflammatory status physical function and cognitive ability through dual task resistance training and detraining in nursing home residents |
| topic | Physical exercise Dual tasking Redox balance Inflammatory profile older adults |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524003085 |
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