Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy
Recent advances in the field of intestinal transplantation have been mitigated by the incidence of allograft rejection. In such events, early identification and appropriate timing of antirejection therapy are crucial in retaining graft function. We present the case of a patient who suffered severe p...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2017/2498423 |
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| _version_ | 1832551553089667072 |
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| author | Cian Wade Philip Allan Elena Collantes Srikanth R. Reddy Peter J. Friend Georgios Vrakas |
| author_facet | Cian Wade Philip Allan Elena Collantes Srikanth R. Reddy Peter J. Friend Georgios Vrakas |
| author_sort | Cian Wade |
| collection | DOAJ |
| description | Recent advances in the field of intestinal transplantation have been mitigated by the incidence of allograft rejection. In such events, early identification and appropriate timing of antirejection therapy are crucial in retaining graft function. We present the case of a patient who suffered severe postintestinal transplantation allograft enteropathy, primarily characterized by extensive mucosal ulcerations, and was refractory to all conventional therapy. This progressed as chronic rejection; however crucially this was not definitively diagnosed until allograft function had irreversibly diminished. We argue that the difficulties encountered in this case can be attributed to the inability of our current array of investigative studies and diagnostic guidelines to provide adequate clinical guidance. This case illustrates the importance of developing reliable and specific markers for guiding the diagnosis of rejection and the use of antirejection therapeutics in this rapidly evolving field of transplant surgery. |
| format | Article |
| id | doaj-art-9503b5d27894402cb88cabf0eeadd933 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-9503b5d27894402cb88cabf0eeadd9332025-02-03T06:01:17ZengWileyCase Reports in Transplantation2090-69432090-69512017-01-01201710.1155/2017/24984232498423Diagnostic Lessons from a Complex Case of Postintestinal Transplantation EnteropathyCian Wade0Philip Allan1Elena Collantes2Srikanth R. Reddy3Peter J. Friend4Georgios Vrakas5University of Oxford Medical Sciences Division, Medical Sciences Office, JR Hospital, Headley Way, Oxford OX3 9DU, UKOxford University Hospitals NHS Foundation Trust, Oxford Transplant Centre, Churchill Hospital, Old Road, Oxford OX3 9DU, UKDepartment of Cellular Pathology, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UKOxford University Hospitals NHS Foundation Trust, Oxford Transplant Centre, Churchill Hospital, Old Road, Oxford OX3 9DU, UKOxford University Hospitals NHS Foundation Trust, Oxford Transplant Centre, Churchill Hospital, Old Road, Oxford OX3 9DU, UKOxford University Hospitals NHS Foundation Trust, Oxford Transplant Centre, Churchill Hospital, Old Road, Oxford OX3 9DU, UKRecent advances in the field of intestinal transplantation have been mitigated by the incidence of allograft rejection. In such events, early identification and appropriate timing of antirejection therapy are crucial in retaining graft function. We present the case of a patient who suffered severe postintestinal transplantation allograft enteropathy, primarily characterized by extensive mucosal ulcerations, and was refractory to all conventional therapy. This progressed as chronic rejection; however crucially this was not definitively diagnosed until allograft function had irreversibly diminished. We argue that the difficulties encountered in this case can be attributed to the inability of our current array of investigative studies and diagnostic guidelines to provide adequate clinical guidance. This case illustrates the importance of developing reliable and specific markers for guiding the diagnosis of rejection and the use of antirejection therapeutics in this rapidly evolving field of transplant surgery.http://dx.doi.org/10.1155/2017/2498423 |
| spellingShingle | Cian Wade Philip Allan Elena Collantes Srikanth R. Reddy Peter J. Friend Georgios Vrakas Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy Case Reports in Transplantation |
| title | Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy |
| title_full | Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy |
| title_fullStr | Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy |
| title_full_unstemmed | Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy |
| title_short | Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy |
| title_sort | diagnostic lessons from a complex case of postintestinal transplantation enteropathy |
| url | http://dx.doi.org/10.1155/2017/2498423 |
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