Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia

Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia

Gilteritinib treats acute myeloid leukemia (AML) with the FMS-like receptor tyrosine kinase-3 (FLT3) internal tandem duplication (ITD) mutation. Dysregulation of histone modification affects the genesis and progression of AML. Strategies targeting key histone regulators have not been applied to the...

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Bibliographic Details
Main Authors: Qi Zhou, Yongyu Guan, Pingping Zhao, Huiyuan Chu, Yaming Xi
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Translational Oncology
Subjects:
Acute myeloid leukemia
FLT3-ITD
Gilteritinib
GSK-J4
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325000026
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