Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use
Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated <i>Salmonella</i> vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stabili...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/12/1319 |
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| author | Domitila Brzoskowski Chagas Francisco Denis Souza Santos Natasha Rodrigues de Oliveira Thaís Larré Oliveira Bohn Odir Antônio Dellagostin |
| author_facet | Domitila Brzoskowski Chagas Francisco Denis Souza Santos Natasha Rodrigues de Oliveira Thaís Larré Oliveira Bohn Odir Antônio Dellagostin |
| author_sort | Domitila Brzoskowski Chagas |
| collection | DOAJ |
| description | Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated <i>Salmonella</i> vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stability of plasmid vectors encoding protective antigens post-immunization. These vaccines are particularly suitable for production animals, providing long-term immunity against a range of bacterial, viral, and parasitic pathogens. This review summarizes the progress made in this field, with a focus on clinical trials demonstrating the efficacy and commercial potential of RASVs in veterinary medicine. |
| format | Article |
| id | doaj-art-94de39ce715a42c6a4e25722950ccc41 |
| institution | DOAJ |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-94de39ce715a42c6a4e25722950ccc412025-08-20T02:43:49ZengMDPI AGVaccines2076-393X2024-11-011212131910.3390/vaccines12121319Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary UseDomitila Brzoskowski Chagas0Francisco Denis Souza Santos1Natasha Rodrigues de Oliveira2Thaís Larré Oliveira Bohn3Odir Antônio Dellagostin4Núcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas 96010-610, Rio Grande do Sul, BrazilNúcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas 96010-610, Rio Grande do Sul, BrazilNúcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas 96010-610, Rio Grande do Sul, BrazilNúcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas 96010-610, Rio Grande do Sul, BrazilNúcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas 96010-610, Rio Grande do Sul, BrazilVaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated <i>Salmonella</i> vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stability of plasmid vectors encoding protective antigens post-immunization. These vaccines are particularly suitable for production animals, providing long-term immunity against a range of bacterial, viral, and parasitic pathogens. This review summarizes the progress made in this field, with a focus on clinical trials demonstrating the efficacy and commercial potential of RASVs in veterinary medicine.https://www.mdpi.com/2076-393X/12/12/1319vaccine development<i>Salmonella</i>attenuationRASVanimal |
| spellingShingle | Domitila Brzoskowski Chagas Francisco Denis Souza Santos Natasha Rodrigues de Oliveira Thaís Larré Oliveira Bohn Odir Antônio Dellagostin Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use Vaccines vaccine development <i>Salmonella</i> attenuation RASV animal |
| title | Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use |
| title_full | Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use |
| title_fullStr | Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use |
| title_full_unstemmed | Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use |
| title_short | Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use |
| title_sort | recombinant live attenuated i salmonella i vaccine for veterinary use |
| topic | vaccine development <i>Salmonella</i> attenuation RASV animal |
| url | https://www.mdpi.com/2076-393X/12/12/1319 |
| work_keys_str_mv | AT domitilabrzoskowskichagas recombinantliveattenuatedisalmonellaivaccineforveterinaryuse AT franciscodenissouzasantos recombinantliveattenuatedisalmonellaivaccineforveterinaryuse AT natasharodriguesdeoliveira recombinantliveattenuatedisalmonellaivaccineforveterinaryuse AT thaislarreoliveirabohn recombinantliveattenuatedisalmonellaivaccineforveterinaryuse AT odirantoniodellagostin recombinantliveattenuatedisalmonellaivaccineforveterinaryuse |