Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use

Recombinant Live-Attenuated <i>Salmonella</i> Vaccine for Veterinary Use

Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated <i>Salmonella</i> vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stabili...

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Bibliographic Details
Main Authors: Domitila Brzoskowski Chagas, Francisco Denis Souza Santos, Natasha Rodrigues de Oliveira, Thaís Larré Oliveira Bohn, Odir Antônio Dellagostin
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
vaccine development
<i>Salmonella</i>
attenuation
RASV
animal
Online Access:https://www.mdpi.com/2076-393X/12/12/1319
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Summary:Vaccination is essential for maintaining animal health, with priority placed on safety and cost effectiveness in veterinary use. The development of recombinant live-attenuated <i>Salmonella</i> vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stability of plasmid vectors encoding protective antigens post-immunization. These vaccines are particularly suitable for production animals, providing long-term immunity against a range of bacterial, viral, and parasitic pathogens. This review summarizes the progress made in this field, with a focus on clinical trials demonstrating the efficacy and commercial potential of RASVs in veterinary medicine.
ISSN:2076-393X

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