An aspirin a day keeps cancer at bay

It has long been hypothesised that aspirin prevents cancer deaths by preventing metastasis. A recent study demonstrates this to be mediated through inhibition of Thromboxane A2 (TXA2) leading to reversal of suppression of T cell immunity. I appraise the context and future research implications of th...

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Main Author: Mangesh A. Thorat
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:BJC Reports
Online Access:https://doi.org/10.1038/s44276-025-00138-1
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author Mangesh A. Thorat
author_facet Mangesh A. Thorat
author_sort Mangesh A. Thorat
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description It has long been hypothesised that aspirin prevents cancer deaths by preventing metastasis. A recent study demonstrates this to be mediated through inhibition of Thromboxane A2 (TXA2) leading to reversal of suppression of T cell immunity. I appraise the context and future research implications of these findings.
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issn 2731-9377
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publisher Nature Portfolio
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series BJC Reports
spelling doaj-art-94c99475204043f1bbf8c63e662411062025-08-20T02:11:46ZengNature PortfolioBJC Reports2731-93772025-04-01311310.1038/s44276-025-00138-1An aspirin a day keeps cancer at bayMangesh A. Thorat0Centre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of LondonIt has long been hypothesised that aspirin prevents cancer deaths by preventing metastasis. A recent study demonstrates this to be mediated through inhibition of Thromboxane A2 (TXA2) leading to reversal of suppression of T cell immunity. I appraise the context and future research implications of these findings.https://doi.org/10.1038/s44276-025-00138-1
spellingShingle Mangesh A. Thorat
An aspirin a day keeps cancer at bay
BJC Reports
title An aspirin a day keeps cancer at bay
title_full An aspirin a day keeps cancer at bay
title_fullStr An aspirin a day keeps cancer at bay
title_full_unstemmed An aspirin a day keeps cancer at bay
title_short An aspirin a day keeps cancer at bay
title_sort aspirin a day keeps cancer at bay
url https://doi.org/10.1038/s44276-025-00138-1
work_keys_str_mv AT mangeshathorat anaspirinadaykeepscanceratbay
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