Epithelial Tight Junctional Changes in Colorectal Cancer Tissues
Colorectal cancer (CRC) is one of the most common cancers in the western world. Early screening and detection could be highly preventative and therefore reduce mortality. Tight junctions (TJ) are well known for their function in controlling paracellular traffic of ions and molecules. It has become i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.86 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558948269424640 |
|---|---|
| author | Xuexuan Wang Owen Tully Benjamin Ngo Marc Zitin James M. Mullin |
| author_facet | Xuexuan Wang Owen Tully Benjamin Ngo Marc Zitin James M. Mullin |
| author_sort | Xuexuan Wang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common cancers in the western world. Early screening and detection could be highly preventative and therefore reduce mortality. Tight junctions (TJ) are well known for their function in controlling paracellular traffic of ions and molecules. It has become increasingly evident that TJs play a crucial role in maintaining cell-cell integrity, and the loss of cell junctional sealing could involve itself in the processes of carcinoma and cancer metastasis. If correlations between altered TJ proteins and CRC presence or invasiveness could be established, they may serve as important markers and guidelines for prophylactic and prognostic purposes, along with other screening methods. This review will present recent data from clinical and animal studies showing how altered TJ protein expression is a feature of certain CRCs. The up-regulation of claudin-1 in many CRCs is especially noteworthy. The focus of this article is simply on the association – however imperfect – between CRC and the major TJ transmembrane barrier proteins, namely claudins and occludin. Any causal relationship between TJ protein change and neoplasia remains conclusively unproven at present. |
| format | Article |
| id | doaj-art-94c913bc6ee24445baf4608479239faf |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-94c913bc6ee24445baf4608479239faf2025-02-03T01:31:15ZengWileyThe Scientific World Journal1537-744X2011-01-011182684110.1100/tsw.2011.86Epithelial Tight Junctional Changes in Colorectal Cancer TissuesXuexuan Wang0Owen Tully1Benjamin Ngo2Marc Zitin3James M. Mullin4Lankenau Institute for Medical Research, Wynnewood, PA, USADivision of Gastroenterology, Lankenau Medical Center, Wynnewood, PA, USADivision of Gastroenterology, Lankenau Medical Center, Wynnewood, PA, USADivision of Gastroenterology, Lankenau Medical Center, Wynnewood, PA, USALankenau Institute for Medical Research, Wynnewood, PA, USAColorectal cancer (CRC) is one of the most common cancers in the western world. Early screening and detection could be highly preventative and therefore reduce mortality. Tight junctions (TJ) are well known for their function in controlling paracellular traffic of ions and molecules. It has become increasingly evident that TJs play a crucial role in maintaining cell-cell integrity, and the loss of cell junctional sealing could involve itself in the processes of carcinoma and cancer metastasis. If correlations between altered TJ proteins and CRC presence or invasiveness could be established, they may serve as important markers and guidelines for prophylactic and prognostic purposes, along with other screening methods. This review will present recent data from clinical and animal studies showing how altered TJ protein expression is a feature of certain CRCs. The up-regulation of claudin-1 in many CRCs is especially noteworthy. The focus of this article is simply on the association – however imperfect – between CRC and the major TJ transmembrane barrier proteins, namely claudins and occludin. Any causal relationship between TJ protein change and neoplasia remains conclusively unproven at present.http://dx.doi.org/10.1100/tsw.2011.86 |
| spellingShingle | Xuexuan Wang Owen Tully Benjamin Ngo Marc Zitin James M. Mullin Epithelial Tight Junctional Changes in Colorectal Cancer Tissues The Scientific World Journal |
| title | Epithelial Tight Junctional Changes in Colorectal Cancer Tissues |
| title_full | Epithelial Tight Junctional Changes in Colorectal Cancer Tissues |
| title_fullStr | Epithelial Tight Junctional Changes in Colorectal Cancer Tissues |
| title_full_unstemmed | Epithelial Tight Junctional Changes in Colorectal Cancer Tissues |
| title_short | Epithelial Tight Junctional Changes in Colorectal Cancer Tissues |
| title_sort | epithelial tight junctional changes in colorectal cancer tissues |
| url | http://dx.doi.org/10.1100/tsw.2011.86 |
| work_keys_str_mv | AT xuexuanwang epithelialtightjunctionalchangesincolorectalcancertissues AT owentully epithelialtightjunctionalchangesincolorectalcancertissues AT benjaminngo epithelialtightjunctionalchangesincolorectalcancertissues AT marczitin epithelialtightjunctionalchangesincolorectalcancertissues AT jamesmmullin epithelialtightjunctionalchangesincolorectalcancertissues |