Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature
The recurrence and treatment resistance of depression remain significant issues, primarily due to an inadequate understanding of its pathogenesis. Recent scientific evidence indicates that gut microbiota influence estradiol metabolism and are associated with the development of depression in nonpreme...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1505991/full |
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| author | Wei Zhang Jinghan Jia Yuhang Yang Dawei Ye Yan Li Di Li Jinxi Wang |
| author_facet | Wei Zhang Jinghan Jia Yuhang Yang Dawei Ye Yan Li Di Li Jinxi Wang |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | The recurrence and treatment resistance of depression remain significant issues, primarily due to an inadequate understanding of its pathogenesis. Recent scientific evidence indicates that gut microbiota influence estradiol metabolism and are associated with the development of depression in nonpremenopausal women. Integrating existing studies on the regulation of estradiol metabolism by microorganisms in nature and the relevance of its degradation products to depression, recent scientific explorations have further elucidated the key mechanisms by which gut microbiota catabolize estradiol through specific metabolic pathways. These emerging scientific findings suggest that the unique metabolic effects of gut microbiota on estradiol may be one of the central drivers in the onset and course of depression in non-menopausal women. |
| format | Article |
| id | doaj-art-94ba592f4685456dbde049ed2e1fc3c3 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-94ba592f4685456dbde049ed2e1fc3c32025-01-28T06:41:28ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011610.3389/fpsyt.2025.15059911505991Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from natureWei Zhang0Jinghan Jia1Yuhang Yang2Dawei Ye3Yan Li4Di Li5Jinxi Wang6Division of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaNeurology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Colorectal Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, ChinaThe recurrence and treatment resistance of depression remain significant issues, primarily due to an inadequate understanding of its pathogenesis. Recent scientific evidence indicates that gut microbiota influence estradiol metabolism and are associated with the development of depression in nonpremenopausal women. Integrating existing studies on the regulation of estradiol metabolism by microorganisms in nature and the relevance of its degradation products to depression, recent scientific explorations have further elucidated the key mechanisms by which gut microbiota catabolize estradiol through specific metabolic pathways. These emerging scientific findings suggest that the unique metabolic effects of gut microbiota on estradiol may be one of the central drivers in the onset and course of depression in non-menopausal women.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1505991/fullgut microbiotawomenestradioldepressiondegradation productsnature |
| spellingShingle | Wei Zhang Jinghan Jia Yuhang Yang Dawei Ye Yan Li Di Li Jinxi Wang Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature Frontiers in Psychiatry gut microbiota women estradiol depression degradation products nature |
| title | Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature |
| title_full | Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature |
| title_fullStr | Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature |
| title_full_unstemmed | Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature |
| title_short | Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature |
| title_sort | estradiol metabolism by gut microbiota in women s depression pathogenesis inspiration from nature |
| topic | gut microbiota women estradiol depression degradation products nature |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1505991/full |
| work_keys_str_mv | AT weizhang estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature AT jinghanjia estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature AT yuhangyang estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature AT daweiye estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature AT yanli estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature AT dili estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature AT jinxiwang estradiolmetabolismbygutmicrobiotainwomensdepressionpathogenesisinspirationfromnature |