Spontaneous Type 2 Diabetic Rodent Models
Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/401723 |
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| _version_ | 1832567662840905728 |
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| author | Yang-wei Wang Guang-dong Sun Jing Sun Shu-jun Liu Ji Wang Xiao-hong Xu Li-ning Miao |
| author_facet | Yang-wei Wang Guang-dong Sun Jing Sun Shu-jun Liu Ji Wang Xiao-hong Xu Li-ning Miao |
| author_sort | Yang-wei Wang |
| collection | DOAJ |
| description | Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes. |
| format | Article |
| id | doaj-art-94b2820fa7f948ef9d2f40192e54082a |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-94b2820fa7f948ef9d2f40192e54082a2025-02-03T01:00:52ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/401723401723Spontaneous Type 2 Diabetic Rodent ModelsYang-wei Wang0Guang-dong Sun1Jing Sun2Shu-jun Liu3Ji Wang4Xiao-hong Xu5Li-ning Miao6Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, Second Hospital of Jilin University, Changchun 130041, ChinaDiabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. Many animal models have been established in order to investigate the mechanisms and pathophysiologic progress of T2DM and find effective treatments for its complications. On the basis of their strains, features, advantages, and disadvantages, various types of animal models of T2DM can be divided into spontaneously diabetic models, artificially induced diabetic models, and transgenic/knockout diabetic models. Among these models, the spontaneous rodent models are used more frequently because many of them can closely describe the characteristic features of T2DM, especially obesity and insulin resistance. In this paper, we aim to investigate the current available spontaneous rodent models for T2DM with regard to their characteristic features, advantages, and disadvantages, and especially to describe appropriate selection and usefulness of different spontaneous rodent models in testing of various new antidiabetic drugs for the treatment of type 2 diabetes.http://dx.doi.org/10.1155/2013/401723 |
| spellingShingle | Yang-wei Wang Guang-dong Sun Jing Sun Shu-jun Liu Ji Wang Xiao-hong Xu Li-ning Miao Spontaneous Type 2 Diabetic Rodent Models Journal of Diabetes Research |
| title | Spontaneous Type 2 Diabetic Rodent Models |
| title_full | Spontaneous Type 2 Diabetic Rodent Models |
| title_fullStr | Spontaneous Type 2 Diabetic Rodent Models |
| title_full_unstemmed | Spontaneous Type 2 Diabetic Rodent Models |
| title_short | Spontaneous Type 2 Diabetic Rodent Models |
| title_sort | spontaneous type 2 diabetic rodent models |
| url | http://dx.doi.org/10.1155/2013/401723 |
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