Osteopontin: Relation between Adipose Tissue and Bone Homeostasis
Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteopor...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/4045238 |
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| author | Carolina De Fusco Antonietta Messina Vincenzo Monda Emanuela Viggiano Fiorenzo Moscatelli Anna Valenzano Teresa Esposito Chieffi Sergio Giuseppe Cibelli Marcellino Monda Giovanni Messina |
| author_facet | Carolina De Fusco Antonietta Messina Vincenzo Monda Emanuela Viggiano Fiorenzo Moscatelli Anna Valenzano Teresa Esposito Chieffi Sergio Giuseppe Cibelli Marcellino Monda Giovanni Messina |
| author_sort | Carolina De Fusco |
| collection | DOAJ |
| description | Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis. |
| format | Article |
| id | doaj-art-94a017997c084a87849244786d9c771a |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-94a017997c084a87849244786d9c771a2025-02-03T05:49:36ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/40452384045238Osteopontin: Relation between Adipose Tissue and Bone HomeostasisCarolina De Fusco0Antonietta Messina1Vincenzo Monda2Emanuela Viggiano3Fiorenzo Moscatelli4Anna Valenzano5Teresa Esposito6Chieffi Sergio7Giuseppe Cibelli8Marcellino Monda9Giovanni Messina10Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, ItalyOsteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.http://dx.doi.org/10.1155/2017/4045238 |
| spellingShingle | Carolina De Fusco Antonietta Messina Vincenzo Monda Emanuela Viggiano Fiorenzo Moscatelli Anna Valenzano Teresa Esposito Chieffi Sergio Giuseppe Cibelli Marcellino Monda Giovanni Messina Osteopontin: Relation between Adipose Tissue and Bone Homeostasis Stem Cells International |
| title | Osteopontin: Relation between Adipose Tissue and Bone Homeostasis |
| title_full | Osteopontin: Relation between Adipose Tissue and Bone Homeostasis |
| title_fullStr | Osteopontin: Relation between Adipose Tissue and Bone Homeostasis |
| title_full_unstemmed | Osteopontin: Relation between Adipose Tissue and Bone Homeostasis |
| title_short | Osteopontin: Relation between Adipose Tissue and Bone Homeostasis |
| title_sort | osteopontin relation between adipose tissue and bone homeostasis |
| url | http://dx.doi.org/10.1155/2017/4045238 |
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