Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice
The major royal jelly proteins (MRJPs) are the central constituents responsible for the specific activities of royal jelly. Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice (FM). Neonatal FM were divide...
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Tsinghua University Press
2020-12-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453020301518 |
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| author | Xin Liu Chenmin Jiang Yong Chen Fangxiong Shi Chaoqiang Lai Lirong Shen |
| author_facet | Xin Liu Chenmin Jiang Yong Chen Fangxiong Shi Chaoqiang Lai Lirong Shen |
| author_sort | Xin Liu |
| collection | DOAJ |
| description | The major royal jelly proteins (MRJPs) are the central constituents responsible for the specific activities of royal jelly. Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice (FM). Neonatal FM were divided into four groups fed MRJPs with doses of 0, 125, 250 and 500 mg/kg/body weight (M125, M250 and M500). The results in M125, M250 and M500 showed that the times of estrus were accelerated by 10.7%, 15.5% and 10.7%, the secondary follicles number were increased by 50.7%, 78.8% and 38.6%, the Graafian follicles were increased by 600.0% and 774.0% and 150.0%, respectively. M500 induced multi-oocyte follicles. The serum estradiol levels of the three groups were increased by 47.1%, 64.9% and 31.1%, the action of MRJPs raising hormone secretion level is mainly via upregulating expression of ERβ gene. Antioxidant parameters of ovarian tissue showed that the malondialdehyde levels in M125 and M250 were decreased, the superoxide dismutase activities and glutathione peroxidase activities in M125 and M250 were increased. In conclusion, MRJPs may accelerate onset of puberty and promote follicular development in FM. Our findings would facilitate better understanding of the benefit effect of MRJPs as the key ingredient in royal jelly on promoting fertility performance. |
| format | Article |
| id | doaj-art-949f306350b24ce79a4014b174d5aef4 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-949f306350b24ce79a4014b174d5aef42025-02-02T23:24:51ZengTsinghua University PressFood Science and Human Wellness2213-45302020-12-0194338345Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female miceXin Liu0Chenmin Jiang1Yong Chen2Fangxiong Shi3Chaoqiang Lai4Lirong Shen5Department of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, ChinaDepartment of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, ChinaDepartment of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, ChinaCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, ChinaUSDA ARS, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111, United StatesDepartment of Food Science and Nutrition, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China; Corresponding author at: Department of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou, China.The major royal jelly proteins (MRJPs) are the central constituents responsible for the specific activities of royal jelly. Here MRJPs via oral administration daily for 45 consecutive days were evaluated the effects on the reproductive parameters in immature female mice (FM). Neonatal FM were divided into four groups fed MRJPs with doses of 0, 125, 250 and 500 mg/kg/body weight (M125, M250 and M500). The results in M125, M250 and M500 showed that the times of estrus were accelerated by 10.7%, 15.5% and 10.7%, the secondary follicles number were increased by 50.7%, 78.8% and 38.6%, the Graafian follicles were increased by 600.0% and 774.0% and 150.0%, respectively. M500 induced multi-oocyte follicles. The serum estradiol levels of the three groups were increased by 47.1%, 64.9% and 31.1%, the action of MRJPs raising hormone secretion level is mainly via upregulating expression of ERβ gene. Antioxidant parameters of ovarian tissue showed that the malondialdehyde levels in M125 and M250 were decreased, the superoxide dismutase activities and glutathione peroxidase activities in M125 and M250 were increased. In conclusion, MRJPs may accelerate onset of puberty and promote follicular development in FM. Our findings would facilitate better understanding of the benefit effect of MRJPs as the key ingredient in royal jelly on promoting fertility performance.http://www.sciencedirect.com/science/article/pii/S2213453020301518Major royal jelly proteinsImmature female micePuberty onsetFollicular developmentAction mechanism |
| spellingShingle | Xin Liu Chenmin Jiang Yong Chen Fangxiong Shi Chaoqiang Lai Lirong Shen Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice Food Science and Human Wellness Major royal jelly proteins Immature female mice Puberty onset Follicular development Action mechanism |
| title | Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice |
| title_full | Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice |
| title_fullStr | Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice |
| title_full_unstemmed | Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice |
| title_short | Major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice |
| title_sort | major royal jelly proteins accelerate onset of puberty and promote ovarian follicular development in immature female mice |
| topic | Major royal jelly proteins Immature female mice Puberty onset Follicular development Action mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453020301518 |
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