Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis

Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis

Abstract Intestinal fibrosis represents a clinically intractable complication in colitis management. This study elucidates the regulatory mechanisms by which bone mesenchymal stem cell-derived exosomes (BMSC-Exo) modulate the myofibroblastic transdifferentiation of intestinal fibroblast. BMSC-Exo wa...

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Bibliographic Details
Main Authors: Fangmei Ling, Wenkai Yang, Meng Yuan, Yidong Chen, Junrong Li, Jinhua Wu, Liangru Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Intestinal fibrosis
Exosomes
Bone marrow mesenchymal stem cells
Connective tissue growth factor
Online Access:https://doi.org/10.1038/s41598-025-02971-3
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