DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN
Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous gland of the skin which can cause depression and anxiety. IL-23 is a cytokine that is involved in autoimmune diseases, including acne vulgaris. IL-23 affects the differentiation process of Th17 which further produces IL...
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Faculty of Medicine, Universitas Diponegoro
2021-07-01
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| Series: | Jurnal Kedokteran Diponegoro |
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| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/30029 |
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| author | Wafi Banadzir Resya Novi Kusumaningrum Santoso Jaeri Astika Widy Utomo |
| author_facet | Wafi Banadzir Resya Novi Kusumaningrum Santoso Jaeri Astika Widy Utomo |
| author_sort | Wafi Banadzir Resya |
| collection | DOAJ |
| description | Background: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous gland of the skin which can cause depression and anxiety. IL-23 is a cytokine that is involved in autoimmune diseases, including acne vulgaris. IL-23 affects the differentiation process of Th17 which further produces IL-17, an important component in the pathogenesis of acne vulgaris. IL-17 plays a significant role in the grade of skin damage caused by the inflammation process.
Objective: To find out differences in IL-23 serum levels and the grade of AV severity in women.
Methods: An observational study with a cross-sectional design approach conducted from June until October 2020 in 15 women with AV aged 15-25 years old, not consuming anti-inflammatory drugs, antibiotics, retinoid group of drugs and free from other inflammatory diseases. Subjects were divided into three groups based on the AV severity grade: specifically mild (n=5), moderate (n=5) and severe (n=5). Subjects had venous blood taken for IL-23 serum content by the ELISA method. Data on IL-23 serum content in the three groups were tested using the One-Way ANOVA method to determine the difference
Results: Average age from the 3 groups was 21 (17-23 ) years old. The results showed that there is no significant difference in IL-23 rate from the 3 groups of AV severities (p=0,490).
Conclusion: : There is no significant difference of IP-23 rate between the 3 groups of AV severites in women. |
| format | Article |
| id | doaj-art-94883af95fd342bfbd2cc3842e8f99c2 |
| institution | DOAJ |
| issn | 2540-8844 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Faculty of Medicine, Universitas Diponegoro |
| record_format | Article |
| series | Jurnal Kedokteran Diponegoro |
| spelling | doaj-art-94883af95fd342bfbd2cc3842e8f99c22025-08-20T03:23:57ZengFaculty of Medicine, Universitas DiponegoroJurnal Kedokteran Diponegoro2540-88442021-07-0110431031510.14710/dmj.v10i4.3002926630DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMENWafi Banadzir Resya0Novi Kusumaningrum1Santoso Jaeri2https://orcid.org/0000-0002-0664-0039Astika Widy Utomo3Dept of Medicine, Faculty of Medicine, Diponegoro University Semarang, IndonesiaDept of Dermatology and Venerology, Faculty of Medicine Diponegoro University Semarang, IndonesiaDept of Medical Biology and Biochemistry Faculty of Medicine Diponegoro University Semarang, IndonesiaDept of Pharmacology and Therapy, Faculty of Medicine Diponegoro University Semarang, IndonesiaBackground: Acne vulgaris is a chronic inflammatory disease in the pilosebaceous gland of the skin which can cause depression and anxiety. IL-23 is a cytokine that is involved in autoimmune diseases, including acne vulgaris. IL-23 affects the differentiation process of Th17 which further produces IL-17, an important component in the pathogenesis of acne vulgaris. IL-17 plays a significant role in the grade of skin damage caused by the inflammation process. Objective: To find out differences in IL-23 serum levels and the grade of AV severity in women. Methods: An observational study with a cross-sectional design approach conducted from June until October 2020 in 15 women with AV aged 15-25 years old, not consuming anti-inflammatory drugs, antibiotics, retinoid group of drugs and free from other inflammatory diseases. Subjects were divided into three groups based on the AV severity grade: specifically mild (n=5), moderate (n=5) and severe (n=5). Subjects had venous blood taken for IL-23 serum content by the ELISA method. Data on IL-23 serum content in the three groups were tested using the One-Way ANOVA method to determine the difference Results: Average age from the 3 groups was 21 (17-23 ) years old. The results showed that there is no significant difference in IL-23 rate from the 3 groups of AV severities (p=0,490). Conclusion: : There is no significant difference of IP-23 rate between the 3 groups of AV severites in women.https://ejournal3.undip.ac.id/index.php/medico/article/view/30029il-23, acne vulgaris, grade of acne vulgaris severity. |
| spellingShingle | Wafi Banadzir Resya Novi Kusumaningrum Santoso Jaeri Astika Widy Utomo DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN Jurnal Kedokteran Diponegoro il-23, acne vulgaris, grade of acne vulgaris severity. |
| title | DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN |
| title_full | DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN |
| title_fullStr | DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN |
| title_full_unstemmed | DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN |
| title_short | DIFFERENCES IN INTERLEUKIN-23 SERUM LEVELS TOWARDS THE SEVERITY OF ACNE VULGARIS IN WOMEN |
| title_sort | differences in interleukin 23 serum levels towards the severity of acne vulgaris in women |
| topic | il-23, acne vulgaris, grade of acne vulgaris severity. |
| url | https://ejournal3.undip.ac.id/index.php/medico/article/view/30029 |
| work_keys_str_mv | AT wafibanadzirresya differencesininterleukin23serumlevelstowardstheseverityofacnevulgarisinwomen AT novikusumaningrum differencesininterleukin23serumlevelstowardstheseverityofacnevulgarisinwomen AT santosojaeri differencesininterleukin23serumlevelstowardstheseverityofacnevulgarisinwomen AT astikawidyutomo differencesininterleukin23serumlevelstowardstheseverityofacnevulgarisinwomen |