A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation
Benign prostatic hyperplasia (BPH) is a common condition in intact male dogs and a leading cause of subfertility. While surgical and chemical castration are effective treatments for BPH, managing this condition in breeding dogs is challenging due to the desire to preserve reproductive function. This...
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MDPI AG
2025-01-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/12/1/70 |
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| author | Florin Petrișor Posastiuc Nicolae Tiberiu Constantin Guillaume Domain Ann Van Soom Alexandru Ilie Diaconescu Mario Darius Codreanu |
| author_facet | Florin Petrișor Posastiuc Nicolae Tiberiu Constantin Guillaume Domain Ann Van Soom Alexandru Ilie Diaconescu Mario Darius Codreanu |
| author_sort | Florin Petrișor Posastiuc |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is a common condition in intact male dogs and a leading cause of subfertility. While surgical and chemical castration are effective treatments for BPH, managing this condition in breeding dogs is challenging due to the desire to preserve reproductive function. This study systematically reviews medical treatments for BPH that maintain breeding potential. Thus, a comprehensive literature search was conducted across four databases (CAB Direct, Scopus, PubMed, and Web of Science) to identify peer-reviewed studies published between 2000 and 2024, following PRISMA guidelines. Specific inclusion and exclusion criteria were applied, and a risk of bias assessment was performed using a modified Cochrane tool. A total of 35 studies were included, evaluating therapies such as finasteride, osaterone acetate, tamoxifen, and others, with outcomes including prostate size, sperm quality, hormonal levels, and tissue morphology. Evidence suggests that osaterone acetate and finasteride are acceptable treatments for BPH in breeding dogs, in spite of a still debatable effect on some sperm characteristics. Therapies like tamoxifen and acyline should be excluded due to their detrimental effects on reproductive function. Further research is required for apparently promising approaches concerning tadalafil, anastrazole, mepartricin, and <i>U. fissa</i>. |
| format | Article |
| id | doaj-art-9477b8625c10401ea3535034280256e2 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Veterinary Sciences |
| spelling | doaj-art-9477b8625c10401ea3535034280256e22025-01-24T13:52:11ZengMDPI AGVeterinary Sciences2306-73812025-01-011217010.3390/vetsci12010070A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function PreservationFlorin Petrișor Posastiuc0Nicolae Tiberiu Constantin1Guillaume Domain2Ann Van Soom3Alexandru Ilie Diaconescu4Mario Darius Codreanu5Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, BelgiumDepartment of Clinical Sciences II, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 050097 Bucharest, RomaniaDepartment of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, BelgiumDepartment of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, BelgiumDepartment of Clinical Sciences II, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 050097 Bucharest, RomaniaDepartment of Clinical Sciences II, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 050097 Bucharest, RomaniaBenign prostatic hyperplasia (BPH) is a common condition in intact male dogs and a leading cause of subfertility. While surgical and chemical castration are effective treatments for BPH, managing this condition in breeding dogs is challenging due to the desire to preserve reproductive function. This study systematically reviews medical treatments for BPH that maintain breeding potential. Thus, a comprehensive literature search was conducted across four databases (CAB Direct, Scopus, PubMed, and Web of Science) to identify peer-reviewed studies published between 2000 and 2024, following PRISMA guidelines. Specific inclusion and exclusion criteria were applied, and a risk of bias assessment was performed using a modified Cochrane tool. A total of 35 studies were included, evaluating therapies such as finasteride, osaterone acetate, tamoxifen, and others, with outcomes including prostate size, sperm quality, hormonal levels, and tissue morphology. Evidence suggests that osaterone acetate and finasteride are acceptable treatments for BPH in breeding dogs, in spite of a still debatable effect on some sperm characteristics. Therapies like tamoxifen and acyline should be excluded due to their detrimental effects on reproductive function. Further research is required for apparently promising approaches concerning tadalafil, anastrazole, mepartricin, and <i>U. fissa</i>.https://www.mdpi.com/2306-7381/12/1/70benign prostatic hyperplasiabreeding dogsfertility preservationsperm qualitymedical therapy |
| spellingShingle | Florin Petrișor Posastiuc Nicolae Tiberiu Constantin Guillaume Domain Ann Van Soom Alexandru Ilie Diaconescu Mario Darius Codreanu A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation Veterinary Sciences benign prostatic hyperplasia breeding dogs fertility preservation sperm quality medical therapy |
| title | A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation |
| title_full | A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation |
| title_fullStr | A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation |
| title_full_unstemmed | A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation |
| title_short | A Systematic Review of Medical Treatments for Benign Prostatic Hyperplasia in Dogs: Evaluating Strategies for Reproductive Function Preservation |
| title_sort | systematic review of medical treatments for benign prostatic hyperplasia in dogs evaluating strategies for reproductive function preservation |
| topic | benign prostatic hyperplasia breeding dogs fertility preservation sperm quality medical therapy |
| url | https://www.mdpi.com/2306-7381/12/1/70 |
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