Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan
Like other persistent organochlorine pesticides, endosulfan residues have been detected in foods including fruit, vegetables, and fish. The aim of our study was to assess the impact of a dietary exposure to low doses of endosulfan from foetal development until adult age on metabolic homeostasis in m...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2013/545802 |
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| author | Cécile Canlet Marie Tremblay-Franco Roselyne Gautier Jérôme Molina Benjamin Métais Florence Blas-Y Estrada Laurence Gamet-Payrastre |
| author_facet | Cécile Canlet Marie Tremblay-Franco Roselyne Gautier Jérôme Molina Benjamin Métais Florence Blas-Y Estrada Laurence Gamet-Payrastre |
| author_sort | Cécile Canlet |
| collection | DOAJ |
| description | Like other persistent organochlorine pesticides, endosulfan residues have been detected in foods including fruit, vegetables, and fish. The aim of our study was to assess the impact of a dietary exposure to low doses of endosulfan from foetal development until adult age on metabolic homeostasis in mice and to identify biomarkers of exposure using an 1H-NMR-based metabonomic approach in various tissues and biofluids. We report in both genders an increase in plasma glucose as well as changes in levels of factors involved in the regulation of liver oxidative stress, confirming the prooxidant activities of this compound. Some metabolic changes were distinct in males and females. For example in plasma, a decrease in lipid LDL and choline content was only observed in female. Lactate levels in males were significantly increased. In conclusion, our results show that metabolic changes in liver could be linked to the onset of pathologies like diabetes and insulin resistance. Moreover from our results it appears that the NMR-based metabonomic approach could be useful for the characterization in plasma of a dietary exposure to low dose of pesticide in human. |
| format | Article |
| id | doaj-art-945d96ce36544004be9f04b0f804a96d |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-945d96ce36544004be9f04b0f804a96d2025-02-03T01:27:51ZengWileyJournal of Toxicology1687-81911687-82052013-01-01201310.1155/2013/545802545802Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of EndosulfanCécile Canlet0Marie Tremblay-Franco1Roselyne Gautier2Jérôme Molina3Benjamin Métais4Florence Blas-Y Estrada5Laurence Gamet-Payrastre6INRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceINRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceINRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceINRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceINRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceINRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceINRA, TOXALIM (Research Centre in Food Toxicology), UMR 1331, INRA/INP/UPS, 31027 Toulouse, FranceLike other persistent organochlorine pesticides, endosulfan residues have been detected in foods including fruit, vegetables, and fish. The aim of our study was to assess the impact of a dietary exposure to low doses of endosulfan from foetal development until adult age on metabolic homeostasis in mice and to identify biomarkers of exposure using an 1H-NMR-based metabonomic approach in various tissues and biofluids. We report in both genders an increase in plasma glucose as well as changes in levels of factors involved in the regulation of liver oxidative stress, confirming the prooxidant activities of this compound. Some metabolic changes were distinct in males and females. For example in plasma, a decrease in lipid LDL and choline content was only observed in female. Lactate levels in males were significantly increased. In conclusion, our results show that metabolic changes in liver could be linked to the onset of pathologies like diabetes and insulin resistance. Moreover from our results it appears that the NMR-based metabonomic approach could be useful for the characterization in plasma of a dietary exposure to low dose of pesticide in human.http://dx.doi.org/10.1155/2013/545802 |
| spellingShingle | Cécile Canlet Marie Tremblay-Franco Roselyne Gautier Jérôme Molina Benjamin Métais Florence Blas-Y Estrada Laurence Gamet-Payrastre Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan Journal of Toxicology |
| title | Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan |
| title_full | Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan |
| title_fullStr | Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan |
| title_full_unstemmed | Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan |
| title_short | Specific Metabolic Fingerprint of a Dietary Exposure to a Very Low Dose of Endosulfan |
| title_sort | specific metabolic fingerprint of a dietary exposure to a very low dose of endosulfan |
| url | http://dx.doi.org/10.1155/2013/545802 |
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