Silicosis: from pathogenesis to therapeutics
Silicosis is an important occupational lung disease caused by exposure to respirable crystalline silica dust particles, with the clinical manifestations from asymptomatic forms to respiratory failure. The main pathological process involves parenchymal lung injury, inflammation and lung tissue fibros...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1516200/full |
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| _version_ | 1832582963225690112 |
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| author | Bijun Yang Xiaoman Liu Cheng Peng Xiangjing Meng Qiang Jia |
| author_facet | Bijun Yang Xiaoman Liu Cheng Peng Xiangjing Meng Qiang Jia |
| author_sort | Bijun Yang |
| collection | DOAJ |
| description | Silicosis is an important occupational lung disease caused by exposure to respirable crystalline silica dust particles, with the clinical manifestations from asymptomatic forms to respiratory failure. The main pathological process involves parenchymal lung injury, inflammation and lung tissue fibrosis, but the exact pathogenesis remains elusive. Until now, there have been no effective treatments for silicosis due to the complexity of pathogenesis and irreversibility of pulmonary fibrosis. In this review we attempt to summarize the advances in pathogenesis and treatment of silicosis and to explore the current understanding of the molecular mechanisms involving in the initiation and development of silicosis and potential therapeutic targets. |
| format | Article |
| id | doaj-art-9442f53fd8f34aa7957318cd22a7c836 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-9442f53fd8f34aa7957318cd22a7c8362025-01-29T06:45:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.15162001516200Silicosis: from pathogenesis to therapeuticsBijun Yang0Xiaoman Liu1Cheng Peng2Xiangjing Meng3Qiang Jia4Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaQueensland Alliance for Environmental Health Sciences, University of Queensland, Brisbane, QLD, AustraliaShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSilicosis is an important occupational lung disease caused by exposure to respirable crystalline silica dust particles, with the clinical manifestations from asymptomatic forms to respiratory failure. The main pathological process involves parenchymal lung injury, inflammation and lung tissue fibrosis, but the exact pathogenesis remains elusive. Until now, there have been no effective treatments for silicosis due to the complexity of pathogenesis and irreversibility of pulmonary fibrosis. In this review we attempt to summarize the advances in pathogenesis and treatment of silicosis and to explore the current understanding of the molecular mechanisms involving in the initiation and development of silicosis and potential therapeutic targets.https://www.frontiersin.org/articles/10.3389/fphar.2025.1516200/fullsilicosispathogenesistherapeuticslung fibrosismolecular mechanisms |
| spellingShingle | Bijun Yang Xiaoman Liu Cheng Peng Xiangjing Meng Qiang Jia Silicosis: from pathogenesis to therapeutics Frontiers in Pharmacology silicosis pathogenesis therapeutics lung fibrosis molecular mechanisms |
| title | Silicosis: from pathogenesis to therapeutics |
| title_full | Silicosis: from pathogenesis to therapeutics |
| title_fullStr | Silicosis: from pathogenesis to therapeutics |
| title_full_unstemmed | Silicosis: from pathogenesis to therapeutics |
| title_short | Silicosis: from pathogenesis to therapeutics |
| title_sort | silicosis from pathogenesis to therapeutics |
| topic | silicosis pathogenesis therapeutics lung fibrosis molecular mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1516200/full |
| work_keys_str_mv | AT bijunyang silicosisfrompathogenesistotherapeutics AT xiaomanliu silicosisfrompathogenesistotherapeutics AT chengpeng silicosisfrompathogenesistotherapeutics AT xiangjingmeng silicosisfrompathogenesistotherapeutics AT qiangjia silicosisfrompathogenesistotherapeutics |