The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome
Abstract Background Placental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying molecular mechanisms remain incompletely understood. This study...
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BMC
2025-01-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07175-1 |
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| author | Filiz Yarsilikal Guleroglu Ali Cetin Goknil Pelin Coskun Meltem Caliskan Fulya Karaduman Can Bilginer Resat Misirlioglu Sinem Tekin Merve Nur Al Tugce Caklili Yusuf Tutar |
| author_facet | Filiz Yarsilikal Guleroglu Ali Cetin Goknil Pelin Coskun Meltem Caliskan Fulya Karaduman Can Bilginer Resat Misirlioglu Sinem Tekin Merve Nur Al Tugce Caklili Yusuf Tutar |
| author_sort | Filiz Yarsilikal Guleroglu |
| collection | DOAJ |
| description | Abstract Background Placental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying molecular mechanisms remain incompletely understood. This study investigates the association between placental syndrome and metabolic alterations in 1-deoxysphingolipids (1-deoxySLs) and polyamines, along with their regulatory enzymes. Methods This prospective case-control study involved 26 healthy pregnant women and 17 with placental syndrome. Blood samples were collected from maternal, uterine venous, and umbilical cord veins. Levels of 1-deoxySL, spermine, and spermidine, as well as related enzymes of polyamine metabolism such as ornithine decarboxylase (ODC), spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO), and spermine oxidase (SMO), were measured using the techniques of LC-MS and ELISA, respectively. Results Women with placental syndrome had significantly higher levels of 1-deoxySL, spermine, and spermidine in all blood samples compared to the healthy pregnancy group. Additionally, ODC and SSAT levels were reduced significantly in the placental syndrome group, while PAO and SMO levels showed no significant differences. Strong positive correlations were found between the studied enzymes and biomolecules in healthy pregnancies, which were notably weaker in the placental syndrome group. Conclusion This study demonstrates significantly altered levels of 1-deoxySL and polyamines, with corresponding enzyme activity changes, in placental syndrome compared to healthy pregnancies. The disrupted correlations between these biomolecules suggest alterations in their metabolic pathways and potential utility as biomarkers. Further mechanistic studies are warranted to elucidate their role in placental syndrome pathophysiology. |
| format | Article |
| id | doaj-art-9442c754d2194254b47c650746269cd6 |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-9442c754d2194254b47c650746269cd62025-01-26T12:57:09ZengBMCBMC Pregnancy and Childbirth1471-23932025-01-0125111210.1186/s12884-025-07175-1The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndromeFiliz Yarsilikal Guleroglu0Ali Cetin1Goknil Pelin Coskun2Meltem Caliskan3Fulya Karaduman4Can Bilginer5Resat Misirlioglu6Sinem Tekin7Merve Nur Al8Tugce Caklili9Yusuf Tutar10Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar UniversityDepartment of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Obstetrics and Gynecology, Haseki Training and Research Hospital, Health Sciences UniversityDepartment of Basic Pharmaceutical Sciences, Division of Biochemistry, Health Sciences UniversityDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Acibadem Mehmet Ali Aydinlar UniversityDepartment of Basic Pharmaceutical Sciences, Division of Biochemistry, Recep Tayyip Erdogan UniversityAbstract Background Placental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying molecular mechanisms remain incompletely understood. This study investigates the association between placental syndrome and metabolic alterations in 1-deoxysphingolipids (1-deoxySLs) and polyamines, along with their regulatory enzymes. Methods This prospective case-control study involved 26 healthy pregnant women and 17 with placental syndrome. Blood samples were collected from maternal, uterine venous, and umbilical cord veins. Levels of 1-deoxySL, spermine, and spermidine, as well as related enzymes of polyamine metabolism such as ornithine decarboxylase (ODC), spermidine/spermine N1-acetyltransferase (SSAT), polyamine oxidase (PAO), and spermine oxidase (SMO), were measured using the techniques of LC-MS and ELISA, respectively. Results Women with placental syndrome had significantly higher levels of 1-deoxySL, spermine, and spermidine in all blood samples compared to the healthy pregnancy group. Additionally, ODC and SSAT levels were reduced significantly in the placental syndrome group, while PAO and SMO levels showed no significant differences. Strong positive correlations were found between the studied enzymes and biomolecules in healthy pregnancies, which were notably weaker in the placental syndrome group. Conclusion This study demonstrates significantly altered levels of 1-deoxySL and polyamines, with corresponding enzyme activity changes, in placental syndrome compared to healthy pregnancies. The disrupted correlations between these biomolecules suggest alterations in their metabolic pathways and potential utility as biomarkers. Further mechanistic studies are warranted to elucidate their role in placental syndrome pathophysiology.https://doi.org/10.1186/s12884-025-07175-1Placental syndromePreeclampsiaFetal growth restriction1-deoxysphingolipidsPolyamines |
| spellingShingle | Filiz Yarsilikal Guleroglu Ali Cetin Goknil Pelin Coskun Meltem Caliskan Fulya Karaduman Can Bilginer Resat Misirlioglu Sinem Tekin Merve Nur Al Tugce Caklili Yusuf Tutar The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome BMC Pregnancy and Childbirth Placental syndrome Preeclampsia Fetal growth restriction 1-deoxysphingolipids Polyamines |
| title | The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome |
| title_full | The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome |
| title_fullStr | The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome |
| title_full_unstemmed | The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome |
| title_short | The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome |
| title_sort | role of 1 deoxysphingolipids and polyamines in the pathogenesis of placental syndrome |
| topic | Placental syndrome Preeclampsia Fetal growth restriction 1-deoxysphingolipids Polyamines |
| url | https://doi.org/10.1186/s12884-025-07175-1 |
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