Cytokines in Endocrine Dysfunction of Plasma Cell Disorders
Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/7586174 |
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| author | Eva Feigerlová Shyue-Fang Battaglia-Hsu |
| author_facet | Eva Feigerlová Shyue-Fang Battaglia-Hsu |
| author_sort | Eva Feigerlová |
| collection | DOAJ |
| description | Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the situation where the presence of M-protein is limited and the serum protein electrophoresis (sPEP) appears normal. To understand the origin of the endocrine symptoms associated with MG, we overview here the current knowledge on the complexity of interactions between cytokines and the endocrine system in MG and discuss the perspectives for both the diagnosis and treatments for this class of diseases. We also illustrate the role of major cytokines and growth factors such as IL-6, IL-1β, TNF-α, and VEGF in the endocrine system, as these tumor-relevant signaling molecules not only help the clonal expansion and invasion of the tumor cells but also influence cellular metabolism through autocrine, paracrine, and endocrine mechanisms. We further discuss the broader impact of these tumor environment-derived molecules and proinflammatory state on systemic hormone signaling. The diagnostic challenges and clinical work-up are illustrated from the point of view of an endocrinologist. |
| format | Article |
| id | doaj-art-943b3a075322485ebbf8e9bb3730b270 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-943b3a075322485ebbf8e9bb3730b2702025-02-03T01:11:55ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/75861747586174Cytokines in Endocrine Dysfunction of Plasma Cell DisordersEva Feigerlová0Shyue-Fang Battaglia-Hsu1CHU de Poitiers, Service d’Endocrinologie, Pole DUNE, Poitiers, FranceINSERM U954, Nutrition Génétique et Exposition aux Risques Environnementaux, Medical Faculty, University of Lorraine and Regional University Hospital Center of Nancy, Vandœuvre-lès-Nancy, FranceMonoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. This concerns especially the situation where the presence of M-protein is limited and the serum protein electrophoresis (sPEP) appears normal. To understand the origin of the endocrine symptoms associated with MG, we overview here the current knowledge on the complexity of interactions between cytokines and the endocrine system in MG and discuss the perspectives for both the diagnosis and treatments for this class of diseases. We also illustrate the role of major cytokines and growth factors such as IL-6, IL-1β, TNF-α, and VEGF in the endocrine system, as these tumor-relevant signaling molecules not only help the clonal expansion and invasion of the tumor cells but also influence cellular metabolism through autocrine, paracrine, and endocrine mechanisms. We further discuss the broader impact of these tumor environment-derived molecules and proinflammatory state on systemic hormone signaling. The diagnostic challenges and clinical work-up are illustrated from the point of view of an endocrinologist.http://dx.doi.org/10.1155/2017/7586174 |
| spellingShingle | Eva Feigerlová Shyue-Fang Battaglia-Hsu Cytokines in Endocrine Dysfunction of Plasma Cell Disorders Mediators of Inflammation |
| title | Cytokines in Endocrine Dysfunction of Plasma Cell Disorders |
| title_full | Cytokines in Endocrine Dysfunction of Plasma Cell Disorders |
| title_fullStr | Cytokines in Endocrine Dysfunction of Plasma Cell Disorders |
| title_full_unstemmed | Cytokines in Endocrine Dysfunction of Plasma Cell Disorders |
| title_short | Cytokines in Endocrine Dysfunction of Plasma Cell Disorders |
| title_sort | cytokines in endocrine dysfunction of plasma cell disorders |
| url | http://dx.doi.org/10.1155/2017/7586174 |
| work_keys_str_mv | AT evafeigerlova cytokinesinendocrinedysfunctionofplasmacelldisorders AT shyuefangbattagliahsu cytokinesinendocrinedysfunctionofplasmacelldisorders |