A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme
In this paper, we develop a mathematical model for the competitionof two species of fibroblast growth factor, FGF-1 and FGF-2, for thesame cell surface receptor. We provide pathways for thisinteraction using experimental data obtained by Neufeld andGospodarowicz reported in 1986 [9]. These pathways...
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| Language: | English |
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AIMS Press
2005-09-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.789 |
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| author | Justin P. Peters Khalid Boushaba Marit Nilsen-Hamilton |
| author_facet | Justin P. Peters Khalid Boushaba Marit Nilsen-Hamilton |
| author_sort | Justin P. Peters |
| collection | DOAJ |
| description | In this paper, we develop a mathematical model for the competitionof two species of fibroblast growth factor, FGF-1 and FGF-2, for thesame cell surface receptor. We provide pathways for thisinteraction using experimental data obtained by Neufeld andGospodarowicz reported in 1986 [9]. These pathwaysdemonstrate how the interaction of two fibroblast growth factorsaffects cell proliferation. Upon development of these pathways, weuse simulations in MATLAB and optimization to extrapolate the valuesof a variety of biochemical parameters imbedded within the model.Furthermore, it should be possible to use the model as the basis fora testable hypothesis. We explore this predictive ability withfurther simulations in MATLAB. |
| format | Article |
| id | doaj-art-9431cefbbba54eb7a76e7b4b2e6e2435 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2005-09-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-9431cefbbba54eb7a76e7b4b2e6e24352025-01-24T01:49:46ZengAIMS PressMathematical Biosciences and Engineering1551-00182005-09-012478981010.3934/mbe.2005.2.789A Mathematical Model for Fibroblast Growth Factor Competition Based on EnzymeJustin P. Peters0Khalid Boushaba1Marit Nilsen-Hamilton2Department of Mathematics, Iowa State University, Carver Hall, Ames, IA 50011Iowa State University, Department of Mathematics, 482 Carver Hall Ames, IA 50011Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Biology Building Ames, IA 50011In this paper, we develop a mathematical model for the competitionof two species of fibroblast growth factor, FGF-1 and FGF-2, for thesame cell surface receptor. We provide pathways for thisinteraction using experimental data obtained by Neufeld andGospodarowicz reported in 1986 [9]. These pathwaysdemonstrate how the interaction of two fibroblast growth factorsaffects cell proliferation. Upon development of these pathways, weuse simulations in MATLAB and optimization to extrapolate the valuesof a variety of biochemical parameters imbedded within the model.Furthermore, it should be possible to use the model as the basis fora testable hypothesis. We explore this predictive ability withfurther simulations in MATLAB.https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.789growth factorsmathematical modelbiological dataoptimization.enzyme kinetics |
| spellingShingle | Justin P. Peters Khalid Boushaba Marit Nilsen-Hamilton A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme Mathematical Biosciences and Engineering growth factors mathematical model biological data optimization. enzyme kinetics |
| title | A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme |
| title_full | A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme |
| title_fullStr | A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme |
| title_full_unstemmed | A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme |
| title_short | A Mathematical Model for Fibroblast Growth Factor Competition Based on Enzyme |
| title_sort | mathematical model for fibroblast growth factor competition based on enzyme |
| topic | growth factors mathematical model biological data optimization. enzyme kinetics |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.789 |
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