The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration

The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration

Abstract Intervertebral disc degeneration (IVDD) is one of the primary causes of low back pain, significantly affecting the quality of life in the elderly population and imposing a substantial economic burden. Currently, clinical treatments for IVDD mainly focus on symptom management, with no availa...

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Bibliographic Details
Main Authors: Xianxu Zhang, Shicheng Li, Xin Liu, Zhong Ma, Qiang Zhang, Yuji Zhang, Jiangdong An, Zhiqiang Luo
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Intervertebral disc degeneration
IVDD
Statins
BMP-2
Simvastatin
Synergistic effect
Online Access:https://doi.org/10.1186/s13018-025-05487-8
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