Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy
Curcumin, a bioactive compound derived from the rhizome of <i>Curcuma longa</i> L., has garnered significant attention for its potent anticancer properties. Despite its promising therapeutic potential, its poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/114 |
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| author | Hicham Wahnou Riad El Kebbaj Bertrand Liagre Vincent Sol Youness Limami Raphaël Emmanuel Duval |
| author_facet | Hicham Wahnou Riad El Kebbaj Bertrand Liagre Vincent Sol Youness Limami Raphaël Emmanuel Duval |
| author_sort | Hicham Wahnou |
| collection | DOAJ |
| description | Curcumin, a bioactive compound derived from the rhizome of <i>Curcuma longa</i> L., has garnered significant attention for its potent anticancer properties. Despite its promising therapeutic potential, its poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers a viable solution to these challenges by enabling the development of curcumin-based nanoparticles (CNPs) that enhance its bioavailability and therapeutic efficacy. This review provides a comprehensive overview of the recent advancements in the design and synthesis of CNPs for cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, and inorganic nanoparticles, highlighting their role in improving curcumin’s pharmacokinetic and pharmacodynamic profiles. The mechanisms by which CNPs exert anticancer effects, such as inducing apoptosis, inhibiting cell proliferation, and modulating signaling pathways, are explored in details. Furthermore, we examine the preclinical and clinical studies that have demonstrated the efficacy of CNPs in treating different types of tumors, including breast, colorectal, and pancreatic cancers. Finally, the review addresses the current challenges and future perspectives in the clinical translation of CNPs, emphasizing the need for further research to optimize their design for targeted delivery and to enhance their therapeutic outcomes. By synthesizing the latest research, this review underscores the potential of CNPs as a promising avenue for advancing cancer therapy. |
| format | Article |
| id | doaj-art-942871f861564c83b2f2ca646dd12494 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-942871f861564c83b2f2ca646dd124942025-01-24T13:46:01ZengMDPI AGPharmaceutics1999-49232025-01-0117111410.3390/pharmaceutics17010114Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor TherapyHicham Wahnou0Riad El Kebbaj1Bertrand Liagre2Vincent Sol3Youness Limami4Raphaël Emmanuel Duval5Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P2693, Maarif, Casablanca 20100, MoroccoLaboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat 26000, MoroccoUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceLaboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat 26000, MoroccoUniversité de Lorraine, F-54000 Nancy, FranceCurcumin, a bioactive compound derived from the rhizome of <i>Curcuma longa</i> L., has garnered significant attention for its potent anticancer properties. Despite its promising therapeutic potential, its poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers a viable solution to these challenges by enabling the development of curcumin-based nanoparticles (CNPs) that enhance its bioavailability and therapeutic efficacy. This review provides a comprehensive overview of the recent advancements in the design and synthesis of CNPs for cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, and inorganic nanoparticles, highlighting their role in improving curcumin’s pharmacokinetic and pharmacodynamic profiles. The mechanisms by which CNPs exert anticancer effects, such as inducing apoptosis, inhibiting cell proliferation, and modulating signaling pathways, are explored in details. Furthermore, we examine the preclinical and clinical studies that have demonstrated the efficacy of CNPs in treating different types of tumors, including breast, colorectal, and pancreatic cancers. Finally, the review addresses the current challenges and future perspectives in the clinical translation of CNPs, emphasizing the need for further research to optimize their design for targeted delivery and to enhance their therapeutic outcomes. By synthesizing the latest research, this review underscores the potential of CNPs as a promising avenue for advancing cancer therapy.https://www.mdpi.com/1999-4923/17/1/114curcuminnanoparticlesbioavailabilitycancer therapytargeted deliveryapoptosis |
| spellingShingle | Hicham Wahnou Riad El Kebbaj Bertrand Liagre Vincent Sol Youness Limami Raphaël Emmanuel Duval Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy Pharmaceutics curcumin nanoparticles bioavailability cancer therapy targeted delivery apoptosis |
| title | Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy |
| title_full | Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy |
| title_fullStr | Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy |
| title_full_unstemmed | Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy |
| title_short | Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy |
| title_sort | curcumin based nanoparticles advancements and challenges in tumor therapy |
| topic | curcumin nanoparticles bioavailability cancer therapy targeted delivery apoptosis |
| url | https://www.mdpi.com/1999-4923/17/1/114 |
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