Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis
The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to insufficient activation of the immune system in...
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2024-12-01
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| Series: | Vestnik Dermatologii i Venerologii |
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| Online Access: | https://vestnikdv.ru/jour/article/viewFile/16820/pdf |
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| author | Margarita R. Rakhmatulina Elena V. Lipova Viktoria A. Nyanenko |
| author_facet | Margarita R. Rakhmatulina Elena V. Lipova Viktoria A. Nyanenko |
| author_sort | Margarita R. Rakhmatulina |
| collection | DOAJ |
| description | The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to insufficient activation of the immune system in the disease. The mechanisms of formation of biofilms by fungi of the genus Candida on mucous membranes and the role of lactobacillary microflora in preventing their spread, as well as ideas about the prerequisites for the development of vulvovaginal candidiasis are considered. The modern possibilities of drug therapy for vulvovaginal candidiasis, presented in domestic and foreign clinical recommendations, are discussed. The advantages of prescribing fenticonazole, which is active against various types of fungi of the genus Candida, as well as a wide range of anaerobes and microorganisms associated with bacterial vaginosis, are considered, and the results of studies on the effectiveness of the drug are analyzed. |
| format | Article |
| id | doaj-art-941ae05c586e4d638889c992aeda1db4 |
| institution | Kabale University |
| issn | 0042-4609 2313-6294 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj-art-941ae05c586e4d638889c992aeda1db42025-02-05T20:41:44ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942024-12-011006304010.25208/vdv168201312Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasisMargarita R. Rakhmatulina0https://orcid.org/0000-0003-3039-7769Elena V. Lipova1https://orcid.org/0000-0001-6490-9529Viktoria A. Nyanenko2State Research Center of Dermatovenereology and CosmetologyA.I. Burnazyan Federal Medical Biophysical CenterPirogov Russian National Research Medical University (Pirogov Medical University)The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to insufficient activation of the immune system in the disease. The mechanisms of formation of biofilms by fungi of the genus Candida on mucous membranes and the role of lactobacillary microflora in preventing their spread, as well as ideas about the prerequisites for the development of vulvovaginal candidiasis are considered. The modern possibilities of drug therapy for vulvovaginal candidiasis, presented in domestic and foreign clinical recommendations, are discussed. The advantages of prescribing fenticonazole, which is active against various types of fungi of the genus Candida, as well as a wide range of anaerobes and microorganisms associated with bacterial vaginosis, are considered, and the results of studies on the effectiveness of the drug are analyzed.https://vestnikdv.ru/jour/article/viewFile/16820/pdfurogenital candidiasiscandidaantimycotic therapyfenticonazole |
| spellingShingle | Margarita R. Rakhmatulina Elena V. Lipova Viktoria A. Nyanenko Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis Vestnik Dermatologii i Venerologii urogenital candidiasis candida antimycotic therapy fenticonazole |
| title | Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis |
| title_full | Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis |
| title_fullStr | Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis |
| title_full_unstemmed | Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis |
| title_short | Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis |
| title_sort | pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis |
| topic | urogenital candidiasis candida antimycotic therapy fenticonazole |
| url | https://vestnikdv.ru/jour/article/viewFile/16820/pdf |
| work_keys_str_mv | AT margaritarrakhmatulina pathogeneticaspectsandmodernpossibilitiesoftherapyofvulvovaginalcandidiasis AT elenavlipova pathogeneticaspectsandmodernpossibilitiesoftherapyofvulvovaginalcandidiasis AT viktoriaanyanenko pathogeneticaspectsandmodernpossibilitiesoftherapyofvulvovaginalcandidiasis |