Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation
Fatigue is an indispensable bioalarm to avoid exhaustive state caused by overwork or stresses. It is necessary to elucidate the neural mechanism of fatigue sensation for managing fatigue properly. We performed H2O 15 positron emission tomography scans to indicate neural activations while subjects w...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2010/671421 |
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| author | Seiki Tajima Shigeyuki Yamamoto Masaaki Tanaka Yosky Kataoka Masao Iwase Etsuji Yoshikawa Hiroyuki Okada Hirotaka Onoe Hideo Tsukada Hirohiko Kuratsune Yasuomi Ouchi Yasuyoshi Watanabe |
| author_facet | Seiki Tajima Shigeyuki Yamamoto Masaaki Tanaka Yosky Kataoka Masao Iwase Etsuji Yoshikawa Hiroyuki Okada Hirotaka Onoe Hideo Tsukada Hirohiko Kuratsune Yasuomi Ouchi Yasuyoshi Watanabe |
| author_sort | Seiki Tajima |
| collection | DOAJ |
| description | Fatigue is an indispensable bioalarm to avoid exhaustive state caused by overwork or stresses. It is necessary to elucidate the neural mechanism of fatigue sensation for managing fatigue properly. We performed H2O 15 positron emission tomography scans to indicate neural activations while subjects were performing 35-min fatigue-inducing task trials twice. During the positron emission tomography experiment, subjects performed advanced trail-making tests, touching the target circles in sequence located on the display of a touch-panel screen. In order to identify the brain regions associated with fatigue sensation, correlation analysis was performed using statistical parametric mapping
method. The brain region exhibiting a positive correlation in activity with subjective sensation of fatigue, measured immediately after each positron emission tomography scan, was located in medial orbitofrontal cortex (Brodmann's area 10/11). Hence, the medial orbitofrontal cortex is a brain region associated with mental fatigue sensation. Our findings provide a new perspective on the neural basis of fatigue. |
| format | Article |
| id | doaj-art-9409e39d1e584ed18c51ae0ec104fc3c |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-9409e39d1e584ed18c51ae0ec104fc3c2025-02-03T06:13:53ZengWileyNeurology Research International2090-18522090-18602010-01-01201010.1155/2010/671421671421Medial Orbitofrontal Cortex Is Associated with Fatigue SensationSeiki Tajima0Shigeyuki Yamamoto1Masaaki Tanaka2Yosky Kataoka3Masao Iwase4Etsuji Yoshikawa5Hiroyuki Okada6Hirotaka Onoe7Hideo Tsukada8Hirohiko Kuratsune9Yasuomi Ouchi10Yasuyoshi Watanabe11Hyogo Children's Sleep and Development Medical Research Center, Hyogo Rehabilitation Centre Central Hospital, 1070 Akebono-cho, Nishi-ku, Kobe 651-2181, JapanResearch Center for Child Mental Development, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, JapanDepartment of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, JapanCenter for Molecular Imaging Science, RIKEN Kobe Institute, 6-7 Minatoshima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, JapanDepartment of Psychiatry, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanCentral Research Laboratory, Hamamatsu Photonics, 5000 Hirakuchi, Hamamatsu, Shizuoka 434-8601, JapanCentral Research Laboratory, Hamamatsu Photonics, 5000 Hirakuchi, Hamamatsu, Shizuoka 434-8601, JapanCenter for Molecular Imaging Science, RIKEN Kobe Institute, 6-7 Minatoshima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, JapanCentral Research Laboratory, Hamamatsu Photonics, 5000 Hirakuchi, Hamamatsu, Shizuoka 434-8601, JapanDepartment of Health Sciences, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, 3-11-1 Asahigaoka, Kashihara, Osaka 582-0026, JapanLaboratory of Human Imaging Research, Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, JapanDepartment of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, JapanFatigue is an indispensable bioalarm to avoid exhaustive state caused by overwork or stresses. It is necessary to elucidate the neural mechanism of fatigue sensation for managing fatigue properly. We performed H2O 15 positron emission tomography scans to indicate neural activations while subjects were performing 35-min fatigue-inducing task trials twice. During the positron emission tomography experiment, subjects performed advanced trail-making tests, touching the target circles in sequence located on the display of a touch-panel screen. In order to identify the brain regions associated with fatigue sensation, correlation analysis was performed using statistical parametric mapping method. The brain region exhibiting a positive correlation in activity with subjective sensation of fatigue, measured immediately after each positron emission tomography scan, was located in medial orbitofrontal cortex (Brodmann's area 10/11). Hence, the medial orbitofrontal cortex is a brain region associated with mental fatigue sensation. Our findings provide a new perspective on the neural basis of fatigue.http://dx.doi.org/10.1155/2010/671421 |
| spellingShingle | Seiki Tajima Shigeyuki Yamamoto Masaaki Tanaka Yosky Kataoka Masao Iwase Etsuji Yoshikawa Hiroyuki Okada Hirotaka Onoe Hideo Tsukada Hirohiko Kuratsune Yasuomi Ouchi Yasuyoshi Watanabe Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation Neurology Research International |
| title | Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation |
| title_full | Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation |
| title_fullStr | Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation |
| title_full_unstemmed | Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation |
| title_short | Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation |
| title_sort | medial orbitofrontal cortex is associated with fatigue sensation |
| url | http://dx.doi.org/10.1155/2010/671421 |
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