Clinical and preclinical insights into a novel MDM2::PDGFRA fusion in recurrent glioblastoma

Clinical and preclinical insights into a novel MDM2::PDGFRA fusion in recurrent glioblastoma

Abstract Glioblastoma is an aggressive and treatment-refractory primary brain tumor with limited therapeutic options and high recurrence. The molecular heterogeneity of glioblastoma poses a significant challenge to therapeutic development, as targeted therapies have mostly failed in small-scale clin...

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Bibliographic Details
Main Authors: Catherine Z. Beach, Christopher A. Febres-Aldana, Juan Luis Gomez Marti, Saeed Asiry, Tamika Wong, John A. Boockvar, Randy S. D’Amico, Romel Somwar, Monika A. Davare, Morana Vojnic
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01076-4
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