O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway

O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway

Abstract Background Lung ischemia–reperfusion (I/R) injury is a common clinical pathology associated with high mortality. The pathophysiology of lung I/R injury involves ferroptosis and elevated protein O-GlcNAcylation levels, while the effect of O-GlcNAcylation on lung I/R injury remains unclear. T...

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Bibliographic Details
Main Authors: Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Biology
Subjects:
Ferroptosis
G6PDH
Lung ischemia–reperfusion
Nrf2
Ogt1
O-GlcNAcylation
Online Access:https://doi.org/10.1186/s12915-025-02126-w
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