A bioinformatics analysis and experimental validation of PDGFD as a promising diagnostic biomarker for acute myeloid leukemia

A bioinformatics analysis and experimental validation of PDGFD as a promising diagnostic biomarker for acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) is a malignant blood cancer resulting from leukemia stem cells (LSCs) supplanting normal stem cells. Platelet-derived growth factors (PDGFs) are important for LSCs but have not been studied in the development of AML. In this study, transcriptome data of PDGFs we...

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Bibliographic Details
Main Authors: Lulu Yang, Shuangshuang Ren, Lijiang Lou, Jiasu He, Qianlei Huang, Xiaojin Wu, Ranran Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Acute myeloid leukemia
PDGF family
NPM1 mutation
Natural killer cell
Prognosis
Online Access:https://doi.org/10.1038/s41598-025-99038-0
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