Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients
Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible associatio...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2014/920491 |
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| author | Mónica Escamilla-Tilch Iris Estrada-García Julio Granados Roberto Arenas-Guzmán Rosalio Ramos-Payan Thalía Gabriela Pérez-Suárez Ma. Isabel Salazar Riky Luis Pérez-Lucas Sergio Estrada-Parra Nora Magdalena Torres-Carrillo |
| author_facet | Mónica Escamilla-Tilch Iris Estrada-García Julio Granados Roberto Arenas-Guzmán Rosalio Ramos-Payan Thalía Gabriela Pérez-Suárez Ma. Isabel Salazar Riky Luis Pérez-Lucas Sergio Estrada-Parra Nora Magdalena Torres-Carrillo |
| author_sort | Mónica Escamilla-Tilch |
| collection | DOAJ |
| description | Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population. |
| format | Article |
| id | doaj-art-93d985e1eb494816aaf6eb92c3bff28b |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-93d985e1eb494816aaf6eb92c3bff28b2025-02-03T01:25:52ZengWileyInternational Journal of Genomics2314-436X2314-43782014-01-01201410.1155/2014/920491920491Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican PatientsMónica Escamilla-Tilch0Iris Estrada-García1Julio Granados2Roberto Arenas-Guzmán3Rosalio Ramos-Payan4Thalía Gabriela Pérez-Suárez5Ma. Isabel Salazar6Riky Luis Pérez-Lucas7Sergio Estrada-Parra8Nora Magdalena Torres-Carrillo9Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, MexicoDepartamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, MexicoDepartamento de Trasplantes, División de Inmunogenética, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14000 México, DF, MexicoSección de Micología, Hospital General Dr. Manuel Gea González, 14080 México, DF, MexicoFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010 Culiacán, SIN, MexicoInstituto Nacional de Geriatría, Periférico Sur No. 2767, Col. San Jerónimo Lídice, Del. Magdalena Contreras, 10200 México, DF, MexicoDepartamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, MexicoDepartamento de Trasplantes, División de Inmunogenética, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14000 México, DF, MexicoDepartamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, MexicoInstituto Nacional de Geriatría, Periférico Sur No. 2767, Col. San Jerónimo Lídice, Del. Magdalena Contreras, 10200 México, DF, MexicoBackground. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.http://dx.doi.org/10.1155/2014/920491 |
| spellingShingle | Mónica Escamilla-Tilch Iris Estrada-García Julio Granados Roberto Arenas-Guzmán Rosalio Ramos-Payan Thalía Gabriela Pérez-Suárez Ma. Isabel Salazar Riky Luis Pérez-Lucas Sergio Estrada-Parra Nora Magdalena Torres-Carrillo Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients International Journal of Genomics |
| title | Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients |
| title_full | Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients |
| title_fullStr | Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients |
| title_full_unstemmed | Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients |
| title_short | Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients |
| title_sort | lack of association of the polymorphisms il 17a 197g a and il 17f 7488a g with multibacillary leprosy in mexican patients |
| url | http://dx.doi.org/10.1155/2014/920491 |
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