Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab
Classical presentation of Histoplasma infection includes fever and respiratory symptoms. Opportunistic microorganisms must be suspected on immunocompromised patients who develop bizarre symptoms. We present a case of a female patient with rheumatoid arthritis who received treatment with Infliximab d...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2013/807537 |
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| author | L. Barrera J. Álvarez M. Tapias V. Idrovo R. López |
| author_facet | L. Barrera J. Álvarez M. Tapias V. Idrovo R. López |
| author_sort | L. Barrera |
| collection | DOAJ |
| description | Classical presentation of Histoplasma infection includes fever and respiratory symptoms. Opportunistic microorganisms must be suspected on immunocompromised patients who develop bizarre symptoms. We present a case of a female patient with rheumatoid arthritis who received treatment with Infliximab during one and a half year; she developed granulomatous hepatitis secondary to Histoplasma infection. The patient was admitted with acute hepatitis and thrombocytopenic coagulopathy. A liver biopsy was performed revealing granulomatous hepatitis, microvesicular steatosis, isolated apoptotic cells, and parenchyma microabscesses. PAS and Gömöri stains revealed areas with mycotic microorganisms morphologically compatible with Histoplasma spp. and confirmed by culture. |
| format | Article |
| id | doaj-art-93d1da8f27d040e7991632447638c4d3 |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-93d1da8f27d040e7991632447638c4d32025-02-03T05:57:46ZengWileyCase Reports in Hepatology2090-65872090-65952013-01-01201310.1155/2013/807537807537Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with InfliximabL. Barrera0J. Álvarez1M. Tapias2V. Idrovo3R. López4Pathology and Clinical Laboratory Department, Fundación Santa Fe de Bogotá Teaching Hospital, Colombia, Calle 119, No. 7-75, Bogotá, ColombiaPathology and Clinical Laboratory Department, Fundación Santa Fe de Bogotá Teaching Hospital, Colombia, Calle 119, No. 7-75, Bogotá, ColombiaGastroenterology Department, Fundación Santa Fe de Bogotá Teaching Hospital, Calle 119, No. 7-75, Bogotá, ColombiaGastroenterology Department, Fundación Santa Fe de Bogotá Teaching Hospital, Calle 119, No. 7-75, Bogotá, ColombiaPathology and Clinical Laboratory Department, Fundación Santa Fe de Bogotá Teaching Hospital, Colombia, Calle 119, No. 7-75, Bogotá, ColombiaClassical presentation of Histoplasma infection includes fever and respiratory symptoms. Opportunistic microorganisms must be suspected on immunocompromised patients who develop bizarre symptoms. We present a case of a female patient with rheumatoid arthritis who received treatment with Infliximab during one and a half year; she developed granulomatous hepatitis secondary to Histoplasma infection. The patient was admitted with acute hepatitis and thrombocytopenic coagulopathy. A liver biopsy was performed revealing granulomatous hepatitis, microvesicular steatosis, isolated apoptotic cells, and parenchyma microabscesses. PAS and Gömöri stains revealed areas with mycotic microorganisms morphologically compatible with Histoplasma spp. and confirmed by culture.http://dx.doi.org/10.1155/2013/807537 |
| spellingShingle | L. Barrera J. Álvarez M. Tapias V. Idrovo R. López Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab Case Reports in Hepatology |
| title | Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab |
| title_full | Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab |
| title_fullStr | Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab |
| title_full_unstemmed | Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab |
| title_short | Granulomatous Hepatitis Secondary to Histoplasma Infection after Treatment with Infliximab |
| title_sort | granulomatous hepatitis secondary to histoplasma infection after treatment with infliximab |
| url | http://dx.doi.org/10.1155/2013/807537 |
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