Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure
Background During the acute heart failure (AHF), acute kidney injury (AKI) is highly prevalent in critically ill patients. The occurrence of the latter condition increases the risk of mortality in patients with acute heart failure. The current research on the relationship between nutritional risk an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2349122 |
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| author | Sen Zhang Nan Chen Zhuo Huang Ningyuan Yan Liansheng Ma Xiaoqin Gao |
| author_facet | Sen Zhang Nan Chen Zhuo Huang Ningyuan Yan Liansheng Ma Xiaoqin Gao |
| author_sort | Sen Zhang |
| collection | DOAJ |
| description | Background During the acute heart failure (AHF), acute kidney injury (AKI) is highly prevalent in critically ill patients. The occurrence of the latter condition increases the risk of mortality in patients with acute heart failure. The current research on the relationship between nutritional risk and the occurrence of acute kidney injury in patients with acute heart failure is very limited.Methods This retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV, version 2.1) database. We included adult patients with AHF who were admitted to the intensive care unit in the study. Results: A total of 1310 critically ill patients with acute heart failure were included. The AUC of geriatric nutritional risk index (GNRI) (0.694) is slightly superior to that of controlling nutritional status (CONUT) (0.656) and prognostic nutritional index (PNI) (0.669). The Log-rank test revealed a higher risk of acute kidney injury in patients with high nutritional risk (p < 0.001). Multivariate COX regression analysis indicated that a high GNRI (adjusted HR 0.62, p < 0.001) was associated with a reduced risk of AKI during hospitalization in AHF patients. The final subgroup analysis demonstrated no significant interaction of GNRI in all subgroups except for diabetes subgroup and ventilation subgroup (P for interaction: 0.057-0.785).Conclusion Our study findings suggest a correlation between GNRI and the occurrence of acute kidney injury in patients hospitalized with acute heart failure. |
| format | Article |
| id | doaj-art-93ca724c4ff54894b07a2d5538176448 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-93ca724c4ff54894b07a2d55381764482025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2349122Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failureSen Zhang0Nan Chen1Zhuo Huang2Ningyuan Yan3Liansheng Ma4Xiaoqin Gao5Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, ChinaDepartment of General Medicine, Xuanwu Hospital of Capital Medical University, Beijing, ChinaDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, ChinaDepartment of Neurology, Datong Coal Mine Group Co Ltd, Datong City, Shanxi Province, ChinaDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, ChinaDepartment of Neurology, First Hospital of Shanxi Medical University, Taiyuan City, Shanxi Province, ChinaBackground During the acute heart failure (AHF), acute kidney injury (AKI) is highly prevalent in critically ill patients. The occurrence of the latter condition increases the risk of mortality in patients with acute heart failure. The current research on the relationship between nutritional risk and the occurrence of acute kidney injury in patients with acute heart failure is very limited.Methods This retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV, version 2.1) database. We included adult patients with AHF who were admitted to the intensive care unit in the study. Results: A total of 1310 critically ill patients with acute heart failure were included. The AUC of geriatric nutritional risk index (GNRI) (0.694) is slightly superior to that of controlling nutritional status (CONUT) (0.656) and prognostic nutritional index (PNI) (0.669). The Log-rank test revealed a higher risk of acute kidney injury in patients with high nutritional risk (p < 0.001). Multivariate COX regression analysis indicated that a high GNRI (adjusted HR 0.62, p < 0.001) was associated with a reduced risk of AKI during hospitalization in AHF patients. The final subgroup analysis demonstrated no significant interaction of GNRI in all subgroups except for diabetes subgroup and ventilation subgroup (P for interaction: 0.057-0.785).Conclusion Our study findings suggest a correlation between GNRI and the occurrence of acute kidney injury in patients hospitalized with acute heart failure.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2349122Acute heart failureacute kidney injurymalnutritionnutrition assessment |
| spellingShingle | Sen Zhang Nan Chen Zhuo Huang Ningyuan Yan Liansheng Ma Xiaoqin Gao Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure Renal Failure Acute heart failure acute kidney injury malnutrition nutrition assessment |
| title | Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure |
| title_full | Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure |
| title_fullStr | Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure |
| title_full_unstemmed | Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure |
| title_short | Geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure |
| title_sort | geriatric nutritional risk index is associated with the occurrence of acute kidney injury in critically ill patients with acute heart failure |
| topic | Acute heart failure acute kidney injury malnutrition nutrition assessment |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2349122 |
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