Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin
Chronic kidney disease is a major public health problem and characterized by a progressive loss in renal function over a period of months or years as defined by structural or functional abnormalities of the kidney. Several elements contribute to determine a progression of the kidney injury, inducing...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/943605 |
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| author | M. Tesauro A. Mascali O. Franzese S. Cipriani C. Cardillo N. Di Daniele |
| author_facet | M. Tesauro A. Mascali O. Franzese S. Cipriani C. Cardillo N. Di Daniele |
| author_sort | M. Tesauro |
| collection | DOAJ |
| description | Chronic kidney disease is a major public health problem and characterized by a progressive loss in renal function over a period of months or years as defined by structural or functional abnormalities of the kidney. Several elements contribute to determine a progression of the kidney injury, inducing a worsening of renal damage and accelerating the decline of renal function: obesity and hypertension are two known factors of kidney progression. Remarkable improvements have been recently achieved in the study of the endocrine features of the adipose tissue and have been able to produce hormone-like peptides named adipokines or adipocytokines. Among these adipocytokines, which represent a link between obesity, hypertension, and chronic nephropathy, leptins and adiponectin appear to play an important role. Leptin not only is a prohypertension element (renal progression factor) through the activation sympathetic nervous, but also is able to induce prosclerotic effects directly on the kidney. In contrast, a decline of adiponectin levels has been shown to be related to a picture of hypertension: an endothelial dysfunction has been described as the main pathogenic mechanism responsible for this phenomenon. |
| format | Article |
| id | doaj-art-93b1d26fa5024b44991ce9d3b58f637d |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-93b1d26fa5024b44991ce9d3b58f637d2025-02-03T01:25:52ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/943605943605Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and AdiponectinM. Tesauro0A. Mascali1O. Franzese2S. Cipriani3C. Cardillo4N. Di Daniele5Division of Internal Medicine, Department of Medicine of the Systems, University of Rome “Tor Vergata”, Rome, ItalyDivision of Nephrology, Department of Medicine of the Systems, University of Rome “Tor Vergata”, Rome, ItalyDivision of Pharmacology, Department of Medicine of the Systems, University of Rome “Tor Vergata”, Rome, ItalyDivision of Nephrology, Department of Medicine of the Systems, University of Rome “Tor Vergata”, Rome, ItalyDepartment of Internal Medicine, “Università Cattolica del Sacro Cuore”, Rome, ItalyDivision of Internal Medicine, Department of Medicine of the Systems, University of Rome “Tor Vergata”, Rome, ItalyChronic kidney disease is a major public health problem and characterized by a progressive loss in renal function over a period of months or years as defined by structural or functional abnormalities of the kidney. Several elements contribute to determine a progression of the kidney injury, inducing a worsening of renal damage and accelerating the decline of renal function: obesity and hypertension are two known factors of kidney progression. Remarkable improvements have been recently achieved in the study of the endocrine features of the adipose tissue and have been able to produce hormone-like peptides named adipokines or adipocytokines. Among these adipocytokines, which represent a link between obesity, hypertension, and chronic nephropathy, leptins and adiponectin appear to play an important role. Leptin not only is a prohypertension element (renal progression factor) through the activation sympathetic nervous, but also is able to induce prosclerotic effects directly on the kidney. In contrast, a decline of adiponectin levels has been shown to be related to a picture of hypertension: an endothelial dysfunction has been described as the main pathogenic mechanism responsible for this phenomenon.http://dx.doi.org/10.1155/2012/943605 |
| spellingShingle | M. Tesauro A. Mascali O. Franzese S. Cipriani C. Cardillo N. Di Daniele Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin International Journal of Hypertension |
| title | Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin |
| title_full | Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin |
| title_fullStr | Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin |
| title_full_unstemmed | Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin |
| title_short | Chronic Kidney Disease, Obesity, and Hypertension: The Role of Leptin and Adiponectin |
| title_sort | chronic kidney disease obesity and hypertension the role of leptin and adiponectin |
| url | http://dx.doi.org/10.1155/2012/943605 |
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