Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions
New azo ligand synthesized from 4, 5-dimethylimidazole, focusing on its coordination properties with copper and zinc divalent ions. The experimental findings confirmed the formation of octahedral geometrical complexes, where the coordination occurs through one nitrogen atom of azo and an N3 atom of...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Plovdiv University Press
2025-01-01
|
| Series: | Journal of BioScience and Biotechnology |
| Subjects: | |
| Online Access: | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/523/382 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583729703288832 |
|---|---|
| author | Husham M. Mubark Israa N. Witwit Hussein A. Ali Salman Mohauman M. Al Rufaie |
| author_facet | Husham M. Mubark Israa N. Witwit Hussein A. Ali Salman Mohauman M. Al Rufaie |
| author_sort | Husham M. Mubark |
| collection | DOAJ |
| description | New azo ligand synthesized from 4, 5-dimethylimidazole, focusing on its coordination properties with copper and zinc divalent ions. The experimental findings confirmed the formation of octahedral geometrical complexes, where the coordination occurs through one nitrogen atom of azo and an N3 atom of imidazole. Evidence from spectroscopic techniques (13-CNMR, Mass, FT-IR, and UV-Vis), conductivity measurements, and magnetic susceptibility supported the structural integrity of the complexes. Biological evaluation showed that the ligand and its complexes possess notable antibacterial properties, particularly the zinc complex, which exhibited stronger inhibitory effects against both Staphylococcus and E. coli bacteria. Antioxidant tests using the DPPH assay indicated that the ligand effectively scavenges free radicals, achieving 70% inhibition at 25 ppm, making it a promising candidate when compared to ascorbic acid. The results underscore the potential of this ligand and its complexes for applications in medicinal chemistry, especially in the development of antimicrobial and antioxidant agents. |
| format | Article |
| id | doaj-art-93ae13057c504edda57abaf2972c22d9 |
| institution | Kabale University |
| issn | 1314-6238 1314-6246 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Plovdiv University Press |
| record_format | Article |
| series | Journal of BioScience and Biotechnology |
| spelling | doaj-art-93ae13057c504edda57abaf2972c22d92025-01-28T07:27:54ZengPlovdiv University PressJournal of BioScience and Biotechnology1314-62381314-62462025-01-0113213313810.69085/jbb20242133Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ionsHusham M. Mubark0Israa N. Witwit1Hussein A. Ali Salman2Mohauman M. Al Rufaie3Chemistry Department, College of Sciences, University of Kufa, Najaf, IraqChemistry Department, College of Sciences, University of Kufa, Najaf, IraqChemistry Department, College of Sciences, University of Kufa, Najaf, IraqChemistry Department, College of Sciences, University of Kufa, Najaf, IraqNew azo ligand synthesized from 4, 5-dimethylimidazole, focusing on its coordination properties with copper and zinc divalent ions. The experimental findings confirmed the formation of octahedral geometrical complexes, where the coordination occurs through one nitrogen atom of azo and an N3 atom of imidazole. Evidence from spectroscopic techniques (13-CNMR, Mass, FT-IR, and UV-Vis), conductivity measurements, and magnetic susceptibility supported the structural integrity of the complexes. Biological evaluation showed that the ligand and its complexes possess notable antibacterial properties, particularly the zinc complex, which exhibited stronger inhibitory effects against both Staphylococcus and E. coli bacteria. Antioxidant tests using the DPPH assay indicated that the ligand effectively scavenges free radicals, achieving 70% inhibition at 25 ppm, making it a promising candidate when compared to ascorbic acid. The results underscore the potential of this ligand and its complexes for applications in medicinal chemistry, especially in the development of antimicrobial and antioxidant agents.https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/523/382azo ligand4’5-dimethylimidazoleantibacterial activityantioxidant activitydpphoctahedral geometryspectroscopic analysis |
| spellingShingle | Husham M. Mubark Israa N. Witwit Hussein A. Ali Salman Mohauman M. Al Rufaie Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions Journal of BioScience and Biotechnology azo ligand 4’5-dimethylimidazole antibacterial activity antioxidant activity dpph octahedral geometry spectroscopic analysis |
| title | Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions |
| title_full | Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions |
| title_fullStr | Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions |
| title_full_unstemmed | Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions |
| title_short | Exploring the coordination, anti-oxidant, and bacterial behavior of a new azo ligand derived from 4,5-dimethylimidazole with copper and zinc divalent ions |
| title_sort | exploring the coordination anti oxidant and bacterial behavior of a new azo ligand derived from 4 5 dimethylimidazole with copper and zinc divalent ions |
| topic | azo ligand 4’5-dimethylimidazole antibacterial activity antioxidant activity dpph octahedral geometry spectroscopic analysis |
| url | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/523/382 |
| work_keys_str_mv | AT hushammmubark exploringthecoordinationantioxidantandbacterialbehaviorofanewazoligandderivedfrom45dimethylimidazolewithcopperandzincdivalentions AT israanwitwit exploringthecoordinationantioxidantandbacterialbehaviorofanewazoligandderivedfrom45dimethylimidazolewithcopperandzincdivalentions AT husseinaalisalman exploringthecoordinationantioxidantandbacterialbehaviorofanewazoligandderivedfrom45dimethylimidazolewithcopperandzincdivalentions AT mohaumanmalrufaie exploringthecoordinationantioxidantandbacterialbehaviorofanewazoligandderivedfrom45dimethylimidazolewithcopperandzincdivalentions |