The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients
Background Chronic liver disease is a common and important clinical problem. Hepatorenal syndrome (HRS) is a life threatening complication. Serum creatinine (Cr) remains the only conventional indicator of renal function. However, the interpretation of serum Cr level can be confounded by malnutrition...
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| Format: | Article |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2346284 |
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| author | Mohamed Adel Abd Elaziz Asmaa Mustafa Gouda Elewa Dina Zaki Mohamed Zaki Abdel Hamid Nohier Essam Soliman Ahmed Hassan Éva Csongrádi Emad Hamdy Hamouda Mohammed Mohammed Abdel Gawad |
| author_facet | Mohamed Adel Abd Elaziz Asmaa Mustafa Gouda Elewa Dina Zaki Mohamed Zaki Abdel Hamid Nohier Essam Soliman Ahmed Hassan Éva Csongrádi Emad Hamdy Hamouda Mohammed Mohammed Abdel Gawad |
| author_sort | Mohamed Adel Abd Elaziz |
| collection | DOAJ |
| description | Background Chronic liver disease is a common and important clinical problem. Hepatorenal syndrome (HRS) is a life threatening complication. Serum creatinine (Cr) remains the only conventional indicator of renal function. However, the interpretation of serum Cr level can be confounded by malnutrition and reduced muscle mass often observed in patients with severe liver disease. Here, we present a cross-sectional study to explore the sensitivity and specificity of other markers as urinary KIM-1 and NGAL for cases of HRS.Methods Cross-sectional study was conducted on 88 patients who were admitted to Alexandria main university hospital. Enrolled patients were divided in two groups; group 1: patients with advanced liver cirrhosis (child B and C) who have normal kidney functions while group 2: patients who developed HRS. Stata© version 14.2 software package was used for analysis.Results Group 1 included 18 males and 26 females compared to 25 males and 19 females in group 2 (p = 0.135). Only the urinary KIM-1 showed a statistically significant difference between both groups in the multivariate logistic regression analysis adjusted for gender, serum bilirubin, serum albumin, INR, serum K, AST and ALT levels.Conclusion In conclusion, our study aligns with prior research, as seen in the consistent findings regarding Urinary NGAL elevation in cirrhotic patients with AKI. Urinary KIM-1, independent of Urinary NGAL, may have a role in precisely distinguishing between advanced liver cirrhosis and HRS and merits further exploration. |
| format | Article |
| id | doaj-art-93aab87571594a859b0d79880f0c3e95 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-93aab87571594a859b0d79880f0c3e952025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2346284The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patientsMohamed Adel Abd Elaziz0Asmaa Mustafa Gouda Elewa1Dina Zaki Mohamed Zaki Abdel Hamid2Nohier Essam Soliman Ahmed Hassan3Éva Csongrádi4Emad Hamdy Hamouda Mohammed5Mohammed Abdel Gawad6Tropical Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, EgyptClinical Pharmacist at Alexandria Hepatology, Gastroenterology and Fever Hospital, EgyptClinical Pharmacist at Zamzam Hospital, Alexandria, EgyptFaculty of Medicine, University of Debrecen, Debrecen, HungaryLecturer of Critical Care, Faculty of Medicine, Alexandria University, Alexandria, EgyptNephrology Unit, Internal Medicine Department, School of Medicine, Newgiza (NGU) University, Giza, EgyptBackground Chronic liver disease is a common and important clinical problem. Hepatorenal syndrome (HRS) is a life threatening complication. Serum creatinine (Cr) remains the only conventional indicator of renal function. However, the interpretation of serum Cr level can be confounded by malnutrition and reduced muscle mass often observed in patients with severe liver disease. Here, we present a cross-sectional study to explore the sensitivity and specificity of other markers as urinary KIM-1 and NGAL for cases of HRS.Methods Cross-sectional study was conducted on 88 patients who were admitted to Alexandria main university hospital. Enrolled patients were divided in two groups; group 1: patients with advanced liver cirrhosis (child B and C) who have normal kidney functions while group 2: patients who developed HRS. Stata© version 14.2 software package was used for analysis.Results Group 1 included 18 males and 26 females compared to 25 males and 19 females in group 2 (p = 0.135). Only the urinary KIM-1 showed a statistically significant difference between both groups in the multivariate logistic regression analysis adjusted for gender, serum bilirubin, serum albumin, INR, serum K, AST and ALT levels.Conclusion In conclusion, our study aligns with prior research, as seen in the consistent findings regarding Urinary NGAL elevation in cirrhotic patients with AKI. Urinary KIM-1, independent of Urinary NGAL, may have a role in precisely distinguishing between advanced liver cirrhosis and HRS and merits further exploration.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2346284Hepatorenal syndromeneutrophil gelatinase-associated lipocalinurinary kidney injury molecule-1serum creatinineliver cirrhosis |
| spellingShingle | Mohamed Adel Abd Elaziz Asmaa Mustafa Gouda Elewa Dina Zaki Mohamed Zaki Abdel Hamid Nohier Essam Soliman Ahmed Hassan Éva Csongrádi Emad Hamdy Hamouda Mohammed Mohammed Abdel Gawad The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients Renal Failure Hepatorenal syndrome neutrophil gelatinase-associated lipocalin urinary kidney injury molecule-1 serum creatinine liver cirrhosis |
| title | The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients |
| title_full | The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients |
| title_fullStr | The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients |
| title_full_unstemmed | The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients |
| title_short | The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients |
| title_sort | use of urinary kidney injury molecule 1 and neutrophil gelatinase associated lipocalin for diagnosis of hepato renal syndrome in advanced cirrhotic patients |
| topic | Hepatorenal syndrome neutrophil gelatinase-associated lipocalin urinary kidney injury molecule-1 serum creatinine liver cirrhosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2346284 |
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