Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity

Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity

Abstract Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the i...

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Main Authors: Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos del Fresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz‐Ezquerro, Ana Cuenda
Format: Article
Language:English
Published: Springer Nature 2018-04-01
Series:EMBO Molecular Medicine
Subjects:
Candida albicans
infection
kinase inhibitor
p38MAPK
signalling
Online Access:https://doi.org/10.15252/emmm.201708485
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