Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting
Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin s...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/757152 |
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| author | Iukary Takenami Brook Finkmoore Almério Machado Krisztina Emodi Lee W. Riley Sérgio Arruda |
| author_facet | Iukary Takenami Brook Finkmoore Almério Machado Krisztina Emodi Lee W. Riley Sérgio Arruda |
| author_sort | Iukary Takenami |
| collection | DOAJ |
| description | Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P≤0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient. |
| format | Article |
| id | doaj-art-939a02726ebd4727a1ec2cec2734a091 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-939a02726ebd4727a1ec2cec2734a0912025-02-03T05:57:49ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/757152757152Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission SettingIukary Takenami0Brook Finkmoore1Almério Machado2Krisztina Emodi3Lee W. Riley4Sérgio Arruda5Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Salvador, Bahia 40296 710, BrazilDivision of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USABahia School of Medicine and Public Health, Salvador, Bahia 40290 000, BrazilDivision of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USADivision of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USAAdvanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Salvador, Bahia 40296 710, BrazilObjectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P≤0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.http://dx.doi.org/10.1155/2012/757152 |
| spellingShingle | Iukary Takenami Brook Finkmoore Almério Machado Krisztina Emodi Lee W. Riley Sérgio Arruda Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting Pulmonary Medicine |
| title | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
| title_full | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
| title_fullStr | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
| title_full_unstemmed | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
| title_short | Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting |
| title_sort | levels of interferon gamma increase after treatment for latent tuberculosis infection in a high transmission setting |
| url | http://dx.doi.org/10.1155/2012/757152 |
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