Meta analysis of resting frontal alpha asymmetry as a biomarker of depression
Abstract This meta-analysis investigated resting frontal alpha asymmetry (FAA) as a potential biomarker for major depressive disorder (MDD). Studies included articles utilizing FAA measure involving EEG electrodes (F3/F4, F7/F8, or Fp1/Fp2) and covering both MDD and controls. Hedges’ d was calculate...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | npj Mental Health Research |
| Online Access: | https://doi.org/10.1038/s44184-025-00117-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594353192697856 |
|---|---|
| author | Yiwen Luo Mingcong Tang Xiwang Fan |
| author_facet | Yiwen Luo Mingcong Tang Xiwang Fan |
| author_sort | Yiwen Luo |
| collection | DOAJ |
| description | Abstract This meta-analysis investigated resting frontal alpha asymmetry (FAA) as a potential biomarker for major depressive disorder (MDD). Studies included articles utilizing FAA measure involving EEG electrodes (F3/F4, F7/F8, or Fp1/Fp2) and covering both MDD and controls. Hedges’ d was calculated from FAA means and standard deviations (SDs). A systematic search of PubMed through July 2023 identified 23 studies involving 1928 MDD participants and 2604 controls. The analysis revealed a small but significant grand mean effect size (ES) for FAA (F4 − F3), suggesting limited diagnostic value of FAA in MDD. Despite the presence of high heterogeneity across studies, subgroup analyses did not identify significant differences based on calculation formula, reference montage, age, or depression severity. The findings indicate that FAA may have limited standalone diagnostic utility but could complement existing clinical assessments for MDD, highlighting the need for a multifaceted approach to depression diagnosis and prognosis. |
| format | Article |
| id | doaj-art-93990a6438454513b890bd221744c44f |
| institution | Kabale University |
| issn | 2731-4251 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Mental Health Research |
| spelling | doaj-art-93990a6438454513b890bd221744c44f2025-01-19T12:43:38ZengNature Portfolionpj Mental Health Research2731-42512025-01-014111010.1038/s44184-025-00117-xMeta analysis of resting frontal alpha asymmetry as a biomarker of depressionYiwen Luo0Mingcong Tang1Xiwang Fan2Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji UniversityClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji UniversityClinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji UniversityAbstract This meta-analysis investigated resting frontal alpha asymmetry (FAA) as a potential biomarker for major depressive disorder (MDD). Studies included articles utilizing FAA measure involving EEG electrodes (F3/F4, F7/F8, or Fp1/Fp2) and covering both MDD and controls. Hedges’ d was calculated from FAA means and standard deviations (SDs). A systematic search of PubMed through July 2023 identified 23 studies involving 1928 MDD participants and 2604 controls. The analysis revealed a small but significant grand mean effect size (ES) for FAA (F4 − F3), suggesting limited diagnostic value of FAA in MDD. Despite the presence of high heterogeneity across studies, subgroup analyses did not identify significant differences based on calculation formula, reference montage, age, or depression severity. The findings indicate that FAA may have limited standalone diagnostic utility but could complement existing clinical assessments for MDD, highlighting the need for a multifaceted approach to depression diagnosis and prognosis.https://doi.org/10.1038/s44184-025-00117-x |
| spellingShingle | Yiwen Luo Mingcong Tang Xiwang Fan Meta analysis of resting frontal alpha asymmetry as a biomarker of depression npj Mental Health Research |
| title | Meta analysis of resting frontal alpha asymmetry as a biomarker of depression |
| title_full | Meta analysis of resting frontal alpha asymmetry as a biomarker of depression |
| title_fullStr | Meta analysis of resting frontal alpha asymmetry as a biomarker of depression |
| title_full_unstemmed | Meta analysis of resting frontal alpha asymmetry as a biomarker of depression |
| title_short | Meta analysis of resting frontal alpha asymmetry as a biomarker of depression |
| title_sort | meta analysis of resting frontal alpha asymmetry as a biomarker of depression |
| url | https://doi.org/10.1038/s44184-025-00117-x |
| work_keys_str_mv | AT yiwenluo metaanalysisofrestingfrontalalphaasymmetryasabiomarkerofdepression AT mingcongtang metaanalysisofrestingfrontalalphaasymmetryasabiomarkerofdepression AT xiwangfan metaanalysisofrestingfrontalalphaasymmetryasabiomarkerofdepression |