Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis
Background and Aims. Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC). Methods. We screened relative studies from Pubmed, Embase, Web o...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/8437250 |
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| author | Hong Lin Jinpeng Yuan Guoxi Liang Yanxuan Wu Liming Chen |
| author_facet | Hong Lin Jinpeng Yuan Guoxi Liang Yanxuan Wu Liming Chen |
| author_sort | Hong Lin |
| collection | DOAJ |
| description | Background and Aims. Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC). Methods. We screened relative studies from Pubmed, Embase, Web of Science, and Cochrane Library. The diagnostic role of circRNAs was testified by pooled sensitivity and specificity. Pooled odds ratio (OR) and pooled hazard ratio (HR) were computed to appraise the clinicopathological and prognostic value, respectively. Results. There were total 15 articles suitable with our included criteria, in which 7 for diagnosis, 8 for prognosis, and 9 for clinicopathological features. The pooled sensitivity and specificity were 0.77 and 0.80, respectively, while the AUC was 0.85. Patients with aberrant expression of circRNAs had a 2.92-fold increased risk of developing EC. The proportion of EC patients with normal circRNA expression only accounted for 29%. Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage. As for prognosis, upregulated expression of circRNA carried out a diverse survival outcome, with a pooled HR of 2.76 for tumor promoter and that of 0.21 for tumor suppressor. High expression of oncogenic circRNA in both plasma and tumor tissue would lead to a shorter survival duration. Conclusion. circRNAs might be a promising biomarker for diagnosis, prognosis, and clinicopathological features of EC. |
| format | Article |
| id | doaj-art-9390fe692ce94897aa641545e7b0ad72 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9390fe692ce94897aa641545e7b0ad722025-02-03T05:52:25ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/84372508437250Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysisHong Lin0Jinpeng Yuan1Guoxi Liang2Yanxuan Wu3Liming Chen4Department of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaDepartment of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaShantou University Medical College, Shantou, Guangdong, ChinaDepartment of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaBackground and Aims. Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC). Methods. We screened relative studies from Pubmed, Embase, Web of Science, and Cochrane Library. The diagnostic role of circRNAs was testified by pooled sensitivity and specificity. Pooled odds ratio (OR) and pooled hazard ratio (HR) were computed to appraise the clinicopathological and prognostic value, respectively. Results. There were total 15 articles suitable with our included criteria, in which 7 for diagnosis, 8 for prognosis, and 9 for clinicopathological features. The pooled sensitivity and specificity were 0.77 and 0.80, respectively, while the AUC was 0.85. Patients with aberrant expression of circRNAs had a 2.92-fold increased risk of developing EC. The proportion of EC patients with normal circRNA expression only accounted for 29%. Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage. As for prognosis, upregulated expression of circRNA carried out a diverse survival outcome, with a pooled HR of 2.76 for tumor promoter and that of 0.21 for tumor suppressor. High expression of oncogenic circRNA in both plasma and tumor tissue would lead to a shorter survival duration. Conclusion. circRNAs might be a promising biomarker for diagnosis, prognosis, and clinicopathological features of EC.http://dx.doi.org/10.1155/2020/8437250 |
| spellingShingle | Hong Lin Jinpeng Yuan Guoxi Liang Yanxuan Wu Liming Chen Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis Gastroenterology Research and Practice |
| title | Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis |
| title_full | Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis |
| title_fullStr | Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis |
| title_full_unstemmed | Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis |
| title_short | Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis |
| title_sort | prognostic and diagnostic significance of circrna expression in esophageal cancer a meta analysis |
| url | http://dx.doi.org/10.1155/2020/8437250 |
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