Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy
Abstract In classical photodynamic therapy, tumor cells are killed by the cytotoxic species via type‐I/II photochemical reactions, seriously limited by the external photoexcitation and hypoxia. Herein, the electron transfer mechanism between fluorophores and peroxalate‐H2O2 reaction is investigated...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411898 |
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| author | Run‐Wei Song Tian‐Ci Jiang Xue‐Yang Zhang Cheng‐Long Shen Qing Lou Chong‐Xin Shan |
| author_facet | Run‐Wei Song Tian‐Ci Jiang Xue‐Yang Zhang Cheng‐Long Shen Qing Lou Chong‐Xin Shan |
| author_sort | Run‐Wei Song |
| collection | DOAJ |
| description | Abstract In classical photodynamic therapy, tumor cells are killed by the cytotoxic species via type‐I/II photochemical reactions, seriously limited by the external photoexcitation and hypoxia. Herein, the electron transfer mechanism between fluorophores and peroxalate‐H2O2 reaction is investigated and the singlet/triplet electron exchange is utilized to achieve long‐persistent chemiluminescence imaging and synergistic type‐I/II/III photodynamic therapy. As a proof‐of‐concept, the photosensitizers of carbon nanodots (CDs)‐loaded chlorin e6 (CDs‐Ce6) are designed and integrated with the peroxalate molecules, and the as‐prepare polymer carbon nanodots (p‐CDs) exhibit novel tumor microenvironment (TME)‐responsive long‐persistent near‐infrared CL and photochemical reactions, evoking the in vivo imaging and synergistic dynamic therapy in tumor tissue. Mechanistically, the excess reactive oxygen species in TME can trigger the chemically initiated singlet/triplet electron exchange between the hydrophobic CDs‐Ce6 and peroxalate‐derived 1,2‐dioxetanes and thus the excess excited singlet/triplet electron of the CDs‐Ce6 can ensure the long‐persistent near‐infrared CL, type I/II photochemical production of hydroxyl radicals, superoxide radical and singlet oxygen, and type III photochemical damage of maladjusted biomacromolecules, enabling the long‐persistent near‐infrared biological imaging and enhanced cancer therapy. These results shed a new sight into the energy transfer mechanism in chemiluminescence and pave a new sight into the architecture of multifunctional theragnostic nanoplatforms. |
| format | Article |
| id | doaj-art-93761e7b2bb0430385f7335b02daefe7 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
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| series | Advanced Science |
| spelling | doaj-art-93761e7b2bb0430385f7335b02daefe72025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202411898Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and TherapyRun‐Wei Song0Tian‐Ci Jiang1Xue‐Yang Zhang2Cheng‐Long Shen3Qing Lou4Chong‐Xin Shan5Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of Education and School of Physics and Laboratory of Zhongyuan Light Zhengzhou University Zhengzhou 450052 ChinaDepartment of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 ChinaCollege of Public Health Zhengzhou University Zhengzhou 450052 ChinaHenan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of Education and School of Physics and Laboratory of Zhongyuan Light Zhengzhou University Zhengzhou 450052 ChinaHenan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of Education and School of Physics and Laboratory of Zhongyuan Light Zhengzhou University Zhengzhou 450052 ChinaHenan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material Physics Ministry of Education and School of Physics and Laboratory of Zhongyuan Light Zhengzhou University Zhengzhou 450052 ChinaAbstract In classical photodynamic therapy, tumor cells are killed by the cytotoxic species via type‐I/II photochemical reactions, seriously limited by the external photoexcitation and hypoxia. Herein, the electron transfer mechanism between fluorophores and peroxalate‐H2O2 reaction is investigated and the singlet/triplet electron exchange is utilized to achieve long‐persistent chemiluminescence imaging and synergistic type‐I/II/III photodynamic therapy. As a proof‐of‐concept, the photosensitizers of carbon nanodots (CDs)‐loaded chlorin e6 (CDs‐Ce6) are designed and integrated with the peroxalate molecules, and the as‐prepare polymer carbon nanodots (p‐CDs) exhibit novel tumor microenvironment (TME)‐responsive long‐persistent near‐infrared CL and photochemical reactions, evoking the in vivo imaging and synergistic dynamic therapy in tumor tissue. Mechanistically, the excess reactive oxygen species in TME can trigger the chemically initiated singlet/triplet electron exchange between the hydrophobic CDs‐Ce6 and peroxalate‐derived 1,2‐dioxetanes and thus the excess excited singlet/triplet electron of the CDs‐Ce6 can ensure the long‐persistent near‐infrared CL, type I/II photochemical production of hydroxyl radicals, superoxide radical and singlet oxygen, and type III photochemical damage of maladjusted biomacromolecules, enabling the long‐persistent near‐infrared biological imaging and enhanced cancer therapy. These results shed a new sight into the energy transfer mechanism in chemiluminescence and pave a new sight into the architecture of multifunctional theragnostic nanoplatforms.https://doi.org/10.1002/advs.202411898biological imagingcarbon nanodotschemiluminescencephotodynamic therapytriplet electron exchange |
| spellingShingle | Run‐Wei Song Tian‐Ci Jiang Xue‐Yang Zhang Cheng‐Long Shen Qing Lou Chong‐Xin Shan Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy Advanced Science biological imaging carbon nanodots chemiluminescence photodynamic therapy triplet electron exchange |
| title | Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy |
| title_full | Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy |
| title_fullStr | Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy |
| title_full_unstemmed | Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy |
| title_short | Triplet Electron Exchange in Carbon Nanodots‐assisted Long‐persistent near‐infrared Chemiluminescence for Oncology Synergistic Imaging and Therapy |
| title_sort | triplet electron exchange in carbon nanodots assisted long persistent near infrared chemiluminescence for oncology synergistic imaging and therapy |
| topic | biological imaging carbon nanodots chemiluminescence photodynamic therapy triplet electron exchange |
| url | https://doi.org/10.1002/advs.202411898 |
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