Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis
Abstract Background The common diagnostic methods for tuberculosis have been showing reduced sensitivity among chronic obstructive pulmonary disease patients. This study was conducted to evaluate and analyse the diagnostic value of an interferon-γ release assay in COPD patients complicated with pulm...
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BMC
2025-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10523-3 |
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| author | Yanxiao Rong Haibin Wang Yuanyuan Su Qian Wang Xuepei Sun Wei Wang |
| author_facet | Yanxiao Rong Haibin Wang Yuanyuan Su Qian Wang Xuepei Sun Wei Wang |
| author_sort | Yanxiao Rong |
| collection | DOAJ |
| description | Abstract Background The common diagnostic methods for tuberculosis have been showing reduced sensitivity among chronic obstructive pulmonary disease patients. This study was conducted to evaluate and analyse the diagnostic value of an interferon-γ release assay in COPD patients complicated with pulmonary tuberculosis. Methods A nested case-control study was conducted on 123 COPD patients hospitalized at the Fifth Hospital of Shijiazhuang, Hebei Province, from January 2019 to June 2021. Thirty-one patients with active pulmonary tuberculosis complicated with COPD composed the observation group (Group A), 31 patients with nonactive pulmonary tuberculosis complicated with COPD composed the COPD control group (Group B), and 31 patients with active pulmonary tuberculosis not complicated with COPD composed the non-COPD control group (Group C). An interferon-γ release assay, a purified protein derivative of tuberculin (PPD) test, an anti-tuberculosis antibody test, a test of Mycobacterium tuberculosis by sputum smear microscopy and a test of Mycobacterium tuberculosis by PCR method were used to test patients in each group. The positive detection rates generated from the five test methods were compared and analysed. Results In COPD patients complicated with active pulmonary tuberculosis, the differences in the percentage of patients with positive interferon-γ release between the PPD test, anti-tuberculosis antibody test, Mycobacterium tuberculosis by sputum smear microscopy and PCR test results were statistically significant. Conclusion In patients with COPD complicated with active pulmonary tuberculosis, the percentage of patients who were positive according to the interferon-γ release assay was higher than that according to the sputum smear microscopy, PCR detection of Mycobacterium tuberculosis in sputum specimen, and detection of anti-tuberculosis antibodies. COPD-related complications did not affect the T-SPOT; the greater the T-SPOT value was, the greater the likelihood of active TB. For patients who are T-SPOT positive but clinically considered to have inactive tuberculosis, regular follow-ups should be performed to observe changes in the patient’s condition. |
| format | Article |
| id | doaj-art-937015a1e43747538432e56b422fc670 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-937015a1e43747538432e56b422fc6702025-01-26T12:16:53ZengBMCBMC Infectious Diseases1471-23342025-01-012511810.1186/s12879-025-10523-3Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosisYanxiao Rong0Haibin Wang1Yuanyuan Su2Qian Wang3Xuepei Sun4Wei Wang5The First Department of Tuberculosis, Fifth Hospital of ShijiazhuangThe First Department of Tuberculosis, Fifth Hospital of ShijiazhuangThe First Department of Tuberculosis, Fifth Hospital of ShijiazhuangThe First Department of Tuberculosis, Fifth Hospital of ShijiazhuangThe First Department of Tuberculosis, Fifth Hospital of ShijiazhuangThe Third Department of Infection, Fifth Hospital of ShijiazhuangAbstract Background The common diagnostic methods for tuberculosis have been showing reduced sensitivity among chronic obstructive pulmonary disease patients. This study was conducted to evaluate and analyse the diagnostic value of an interferon-γ release assay in COPD patients complicated with pulmonary tuberculosis. Methods A nested case-control study was conducted on 123 COPD patients hospitalized at the Fifth Hospital of Shijiazhuang, Hebei Province, from January 2019 to June 2021. Thirty-one patients with active pulmonary tuberculosis complicated with COPD composed the observation group (Group A), 31 patients with nonactive pulmonary tuberculosis complicated with COPD composed the COPD control group (Group B), and 31 patients with active pulmonary tuberculosis not complicated with COPD composed the non-COPD control group (Group C). An interferon-γ release assay, a purified protein derivative of tuberculin (PPD) test, an anti-tuberculosis antibody test, a test of Mycobacterium tuberculosis by sputum smear microscopy and a test of Mycobacterium tuberculosis by PCR method were used to test patients in each group. The positive detection rates generated from the five test methods were compared and analysed. Results In COPD patients complicated with active pulmonary tuberculosis, the differences in the percentage of patients with positive interferon-γ release between the PPD test, anti-tuberculosis antibody test, Mycobacterium tuberculosis by sputum smear microscopy and PCR test results were statistically significant. Conclusion In patients with COPD complicated with active pulmonary tuberculosis, the percentage of patients who were positive according to the interferon-γ release assay was higher than that according to the sputum smear microscopy, PCR detection of Mycobacterium tuberculosis in sputum specimen, and detection of anti-tuberculosis antibodies. COPD-related complications did not affect the T-SPOT; the greater the T-SPOT value was, the greater the likelihood of active TB. For patients who are T-SPOT positive but clinically considered to have inactive tuberculosis, regular follow-ups should be performed to observe changes in the patient’s condition.https://doi.org/10.1186/s12879-025-10523-3COPDPulmonary tuberculosisInterferon-γ release assay |
| spellingShingle | Yanxiao Rong Haibin Wang Yuanyuan Su Qian Wang Xuepei Sun Wei Wang Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis BMC Infectious Diseases COPD Pulmonary tuberculosis Interferon-γ release assay |
| title | Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis |
| title_full | Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis |
| title_fullStr | Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis |
| title_full_unstemmed | Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis |
| title_short | Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis |
| title_sort | diagnostic value of interferon γ release assay in patients with copd complicated with pulmonary tuberculosis |
| topic | COPD Pulmonary tuberculosis Interferon-γ release assay |
| url | https://doi.org/10.1186/s12879-025-10523-3 |
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