Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential
Phosphodegrons are critical motifs that play a pivotal role in the regulation of protein stability and function via phosphorylation-dependent signaling pathways. These motifs serve as recognition elements for ubiquitin ligases, facilitating the targeted degradation of proteins. By modulating key cel...
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MDPI AG
2025-02-01
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| Series: | Kinases and Phosphatases |
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| Online Access: | https://www.mdpi.com/2813-3757/3/1/3 |
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| author | Tadashi Nakagawa Makiko Nakagawa |
| author_facet | Tadashi Nakagawa Makiko Nakagawa |
| author_sort | Tadashi Nakagawa |
| collection | DOAJ |
| description | Phosphodegrons are critical motifs that play a pivotal role in the regulation of protein stability and function via phosphorylation-dependent signaling pathways. These motifs serve as recognition elements for ubiquitin ligases, facilitating the targeted degradation of proteins. By modulating key cellular processes such as cell cycle progression, DNA repair, and apoptosis, phosphodegrons are essential for maintaining cellular homeostasis. Dysregulation of phosphodegrons has been implicated in a wide range of diseases, including cancer and neurodegenerative disorders, highlighting their potential as therapeutic targets. This review provides an overview of phosphodegron functions along with their biological significance in health and disease. Additionally, we discuss current methodologies for studying phosphodegrons and explore emerging trends in their identification and therapeutic targeting. By synthesizing recent advances in the field, this article aims to offer insights into the future directions and challenges in phosphodegron research, ultimately underscoring their importance in cellular regulation and disease pathology. |
| format | Article |
| id | doaj-art-9364c22aa7484cb3917b5f0c9e03c0da |
| institution | OA Journals |
| issn | 2813-3757 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Kinases and Phosphatases |
| spelling | doaj-art-9364c22aa7484cb3917b5f0c9e03c0da2025-08-20T01:49:00ZengMDPI AGKinases and Phosphatases2813-37572025-02-0131310.3390/kinasesphosphatases3010003Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic PotentialTadashi Nakagawa0Makiko Nakagawa1Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Sanyo-Onoda 756-0084, JapanInstitute of Gene Research, Yamaguchi University Science Research Center, Yamaguchi 755-8505, JapanPhosphodegrons are critical motifs that play a pivotal role in the regulation of protein stability and function via phosphorylation-dependent signaling pathways. These motifs serve as recognition elements for ubiquitin ligases, facilitating the targeted degradation of proteins. By modulating key cellular processes such as cell cycle progression, DNA repair, and apoptosis, phosphodegrons are essential for maintaining cellular homeostasis. Dysregulation of phosphodegrons has been implicated in a wide range of diseases, including cancer and neurodegenerative disorders, highlighting their potential as therapeutic targets. This review provides an overview of phosphodegron functions along with their biological significance in health and disease. Additionally, we discuss current methodologies for studying phosphodegrons and explore emerging trends in their identification and therapeutic targeting. By synthesizing recent advances in the field, this article aims to offer insights into the future directions and challenges in phosphodegron research, ultimately underscoring their importance in cellular regulation and disease pathology.https://www.mdpi.com/2813-3757/3/1/3phosphodegronsubiquitin–proteasome system (UPS)ubiquitin ligasesprotein degradationprotein phosphorylationdisease pathology |
| spellingShingle | Tadashi Nakagawa Makiko Nakagawa Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential Kinases and Phosphatases phosphodegrons ubiquitin–proteasome system (UPS) ubiquitin ligases protein degradation protein phosphorylation disease pathology |
| title | Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential |
| title_full | Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential |
| title_fullStr | Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential |
| title_full_unstemmed | Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential |
| title_short | Phosphodegrons in Health and Disease: From Cellular Homeostasis to Therapeutic Potential |
| title_sort | phosphodegrons in health and disease from cellular homeostasis to therapeutic potential |
| topic | phosphodegrons ubiquitin–proteasome system (UPS) ubiquitin ligases protein degradation protein phosphorylation disease pathology |
| url | https://www.mdpi.com/2813-3757/3/1/3 |
| work_keys_str_mv | AT tadashinakagawa phosphodegronsinhealthanddiseasefromcellularhomeostasistotherapeuticpotential AT makikonakagawa phosphodegronsinhealthanddiseasefromcellularhomeostasistotherapeuticpotential |